De Wilde V, Vogelaers D, Colardyn F
Intensive Care Department, University Hospital of Ghent, Belgium.
Klin Wochenschr. 1990 Jun 19;68(12):615-8. doi: 10.1007/BF01660960.
In organophosphate intoxication the assessment of both the degree of severity of poisoning and the initial dose of pralidoxime and atropine are as yet based only on clinical symptoms. We present three patients with clinically severe organophosphate poisoning in whom a prompt recovery from central nervous symptoms occurred after the administration of low doses of atropine and pralidoxime. It is suggested that the true severity of organophosphate intoxication as well as the initial therapy should be determined by the amount ingested, the propensity for aging, and the pharmacodynamic properties of the organophosphorus compound, as well as by the time interval between exposure and initiation of appropriate treatment, as far as these data can be verified in the individual patient.
在有机磷中毒时，中毒严重程度的评估以及解磷定和阿托品的初始剂量目前仅基于临床症状。我们报告了3例临床重度有机磷中毒患者，他们在给予低剂量阿托品和解磷定后，中枢神经症状迅速恢复。有人提出，有机磷中毒的真正严重程度以及初始治疗应根据摄入的量、老化倾向、有机磷化合物的药效学特性，以及暴露与开始适当治疗之间的时间间隔来确定，只要这些数据能在个体患者中得到验证。
