Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, United States.
Physiol Behav. 2013 Jul 2;119:79-85. doi: 10.1016/j.physbeh.2013.06.012. Epub 2013 Jun 13.
The current study investigated whether internal pain-inducing agents can modulate palatability of a tastant in the same way as illness-inducing agents (e.g., lithium chloride). Similar to traditional conditioned taste aversion (CTA) experiments, during conditioning the rats were exposed to a saccharin solution followed by intraperitoneal injections of either gallamine (Experiment 1) or hypertonic sodium chloride (NaCl; Experiments 1 and 2). In addition to the total amount consumed, the time of each lick was recorded for lick pattern analysis. The results showed that both gallamine and hypertonic NaCl caused suppression in saccharin intake. Importantly, both lick cluster size and initial lick rate (the measures of taste palatability) were reduced as well. This pattern of results suggests that these pain-inducing agents reduce the hedonic value of the associated tastant and thus CTA is acquired. The current finding serves as evidence supporting the view that CTA is a broadly tuned mechanism that can be triggered by changes in internal body states following consummatory experience.
本研究旨在探讨内源性致痛剂是否能以与致病剂（如氯化锂）相同的方式调节味觉的可口性。与传统的条件性味觉厌恶（CTA）实验类似，在实验中，大鼠在暴露于蔗糖溶液后，分别接受箭毒（实验 1）或高渗氯化钠（NaCl；实验 1 和 2）的腹腔内注射。除了总消耗量外，还记录了每次舔舐的时间，以进行舔舐模式分析。结果表明，箭毒和高渗 NaCl 均导致蔗糖摄入减少。重要的是，舔舐簇大小和初始舔舐率（味觉可口性的衡量指标）也降低了。这种结果模式表明，这些致痛剂降低了与味觉相关的味觉的愉悦价值，因此获得了 CTA。这一发现为 CTA 是一种广泛调节的机制的观点提供了证据，该机制可以在摄食体验后由内部身体状态的变化引发。
