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麻醉诱导药物也会引起条件性味觉厌恶。

Anesthesia-inducing drugs also induce conditioned taste aversions.

机构信息

University of Illinois at Chicago, United States.

University of Illinois at Chicago, United States.

出版信息

Physiol Behav. 2017 Aug 1;177:247-251. doi: 10.1016/j.physbeh.2017.05.010. Epub 2017 May 9.

DOI:10.1016/j.physbeh.2017.05.010
PMID:28499795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5857295/
Abstract

Animals learn to reduce their intake of a tastant when its ingestion is followed by the administration of an anesthesia-inducing drug. To determine the nature of this intake suppression, the current study examined whether ketamine/xylazine (Experiment 1) and pentobarbital (Experiment 2) also conditionally reduce taste palatability. Using lick pattern analysis, we found that pairing saccharin with either drug reduced total licks, lick cluster size, and initial lick rate. Given that both lick cluster size and initial lick rate are indices of palatability, this pattern of results indicates that anesthesia-inducing drugs also induce conditioned taste aversions.

摘要

当动物摄入某种味觉物质后随即给予麻醉诱导药物，它们会学会减少这种味觉物质的摄入量。为了确定这种摄入抑制的本质，本研究通过实验 1 检验了氯胺酮/二甲噻嗪和实验 2 检验了戊巴比妥是否也能条件性地降低味觉的可口性。通过舔舐模式分析，我们发现，将蔗糖与这两种药物中的任意一种进行配对，都会减少总的舔舐次数、舔舐簇大小和初始舔舐率。鉴于舔舐簇大小和初始舔舐率都是可口性的指标，这种结果模式表明，麻醉诱导药物也会引起条件性味觉厌恶。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec2/5857295/0167b484295c/nihms949485f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec2/5857295/d826792cf978/nihms949485f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec2/5857295/0167b484295c/nihms949485f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec2/5857295/d826792cf978/nihms949485f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec2/5857295/0167b484295c/nihms949485f2.jpg

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本文引用的文献

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Conditioned taste aversion, drugs of abuse and palatability.条件性味觉厌恶、成瘾性药物与适口性
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Reduced palatability in pain-induced conditioned taste aversions.疼痛诱导的条件味觉厌恶反应中味觉适口性降低。
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Reduced palatability in drug-induced taste aversion: I. Variations in the initial value of the conditioned stimulus.药物诱导性味觉厌恶中的适口性降低：I. 条件刺激初始值的变化
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Reduced palatability in drug-induced taste aversion: II. Aversive and rewarding unconditioned stimuli.药物诱导性味觉厌恶中的适口性降低：II. 厌恶和奖赏性非条件刺激
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