Kocaeli University Medical School, Department of Dermatology, Kocaeli, Turkey.
Physiol Behav. 2013 Jul 2;119:145-8. doi: 10.1016/j.physbeh.2013.06.010. Epub 2013 Jun 13.
Growing evidence indicates that there is a correlation between depression and inflammation. Administration of anti-tumor necrosis factor (TNF) agents for treatment of chronic inflammatory diseases, such as psoriasis, was associated with decreased depressive symptoms and increased quality of life in some clinical studies. The aim of the present study was to investigate the effects of chronic etanercept, a TNF-α inhibitor, on anxiety- and depression-like neurobehaviors in rats. Male rats were treated for 8 weeks with either saline or etanercept (0.8 mg/kg/week, subcutaneously). The anxiety levels of rats were evaluated using the elevated plus maze, a classical rodent model of anxiety and depression was measured using the force swimming test, a behavioral despair task. The anxiety-like neurobehaviors of the animals were found significantly decreased after the etanercept treatment. Etanercept significantly decreased immobility time in rat model of despair test, seemed to have an antidepressive effect in rats. Compared to saline treatment, long-term etanercept treatment had no effect on the total number and pattern of locomotor activities. Findings of the study supported the hypothesis that TNF-α has a role in the modulation of emotional processes and its inhibition may represent a novel strategy for the treatment of affective disorders.
越来越多的证据表明，抑郁和炎症之间存在相关性。在一些临床研究中，使用抗肿瘤坏死因子 (TNF) 药物治疗慢性炎症性疾病，如银屑病，与抑郁症状减轻和生活质量提高有关。本研究旨在探讨 TNF-α抑制剂依那西普对大鼠焦虑和抑郁样神经行为的影响。雄性大鼠连续 8 周接受生理盐水或依那西普（0.8mg/kg/周，皮下注射）治疗。使用高架十字迷宫评估大鼠的焦虑水平，使用强迫游泳试验，一种行为绝望任务来测量抑郁样行为。结果发现，依那西普治疗后动物的焦虑样神经行为显著减少。依那西普显著降低了绝望试验中大鼠的不动时间，似乎对大鼠具有抗抑郁作用。与生理盐水治疗相比，长期依那西普治疗对总运动次数和模式没有影响。研究结果支持 TNF-α 在调节情绪过程中起作用的假设，其抑制可能代表治疗情感障碍的一种新策略。
