Nikoletopoulou Vassiliki, Markaki Maria, Palikaras Konstantinos, Tavernarakis Nektarios
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.
Biochim Biophys Acta. 2013 Dec;1833(12):3448-3459. doi: 10.1016/j.bbamcr.2013.06.001. Epub 2013 Jun 13.
Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.
凋亡和坏死是细胞死亡的两种主要方式，其分子机制已得到广泛研究。尽管最初认为这两种方式代表相互排斥的细胞状态，但最近的研究结果表明，在某些细胞环境中，这两种细胞死亡方式需要相互平衡、共同作用。通过构成共同模块或作为一种开关，使细胞根据具体情况决定采取哪种死亡途径，一些死亡起始和效应分子、信号通路及亚细胞位点已被确定为这两个过程的关键介质。重要的是，自噬作为一种主要的细胞保护过程，已被证明与这两种细胞死亡方式都有关联，发挥着促生存或促死亡的作用。在此，我们综述了近期的文献，这些文献突出了凋亡、坏死和自噬之间复杂的相互作用，重点关注这种相互作用在正常发育和病理学中的相关性及影响。本文是名为“细胞死亡途径”的特刊的一部分。
