Provencher Thierry, Fecteau Shirley, Bastien Célyne H
School of Psychology, Laval University, Quebec, QC G1V 0A6, Canada.
CERVO Brain Research Center, Centre Intégré Universitaire en Santé et Services Sociaux de la Capitale-Nationale, Quebec, QC G1V 0A6, Canada.
Brain Sci. 2020 Dec 19;10(12):1014. doi: 10.3390/brainsci10121014.
Individuals with insomnia present unique patterns of electroencephalographic (EEG) asymmetry between homologous regions of each brain hemisphere, yet few studies have assessed asymmetry within the same hemisphere. Increase in intrahemispheric asymmetry during rapid eye movement (REM) sleep in good sleepers (GS) and disruption of REM sleep in insomnia sufferers (INS) both point out that this activity may be involved in the pathology of insomnia. The objective of the present exploratory study was to evaluate and quantify patterns of fronto-central, fronto-parietal, fronto-occipital, centro-parietal, centro-occipital and parieto-occipital intrahemispheric asymmetry in GS and INS, and to assess their association with sleep-wake misperception, daytime anxiety and depressive symptoms, as well as insomnia severity. This paper provides secondary analysis of standard EEG recorded in 43 INS and 19 GS for three nights in a sleep laboratory. Asymmetry measures were based on EEG power spectral analysis within 0.3-60 Hz computed between pairs of regions at frontal, central, parietal and occipital derivations. Repeated-measures ANOVAs were performed to assess group differences. Exploratory correlations were then performed on asymmetry and sleep-wake misperception, as well as self-reported daytime anxiety and depressive symptoms, and insomnia severity. INS presented increased delta and theta F3/P3 asymmetry during REM sleep compared with GS, positively associated with depressive and insomnia complaints. INS also exhibited decreased centro-occipital (C3/O1, C4/O2) and parieto-occipital (P3-O1, P4/O2) theta asymmetry during REM. These findings suggest that INS present specific patterns of intrahemispheric asymmetry, partially related to their clinical symptoms. Future studies may investigate the extent to which asymmetry is related to sleep-wake misperception or memory impairments.
失眠患者在每个脑半球的同源区域之间呈现出独特的脑电图（EEG）不对称模式，但很少有研究评估同一半球内的不对称情况。睡眠良好者（GS）在快速眼动（REM）睡眠期间半球内不对称性增加，而失眠患者（INS）的REM睡眠受到干扰，这两者都表明这种活动可能与失眠的病理机制有关。本探索性研究的目的是评估和量化GS和INS中额中央、额顶、额枕、中央顶、中央枕和顶枕半球内不对称的模式，并评估它们与睡眠-觉醒错误认知、白天焦虑和抑郁症状以及失眠严重程度的关联。本文对在睡眠实验室中43名INS和19名GS连续三晚记录的标准脑电图进行了二次分析。不对称测量基于在额、中央、顶和枕导联的区域对之间计算的0.3 - 60 Hz范围内的EEG功率谱分析。进行重复测量方差分析以评估组间差异。然后对不对称性与睡眠-觉醒错误认知、自我报告的白天焦虑和抑郁症状以及失眠严重程度进行探索性相关性分析。与GS相比，INS在REM睡眠期间表现出δ波和θ波F3/P3不对称性增加，与抑郁和失眠主诉呈正相关。INS在REM期间还表现出中央枕（C3/O1、C4/O2）和顶枕（P3 - O1、P4/O2）θ波不对称性降低。这些发现表明INS呈现出特定的半球内不对称模式，部分与它们的临床症状相关。未来的研究可以调查不对称性与睡眠-觉醒错误认知或记忆障碍的相关程度。
