Department of Psychology and Center for Mind and Brain, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Neuropsychologia. 2013 Oct;51(12):2415-26. doi: 10.1016/j.neuropsychologia.2013.05.026. Epub 2013 Jun 13.
The goal of the present study was to examine age-related differences in hippocampal and cortical contribution to episodic retrieval of spatial context in 3 age groups. Children ages 8-9 and 10-11 years old, and adults ages 18-25 (N=48) encoded black and white line drawings appearing either on the right side or the left side of a screen. Functional magnetic resonance imaging (fMRI) data were acquired while participants attempted to recall where each studied drawing had originally appeared. Correct recall of spatial source indicated successful episodic retrieval of spatial context. Activity in head and body of the hippocampus was associated with episodic retrieval in adults, but not in children. In children, individual differences in hippocampal activation for recognition predicted rates of correct spatial recall. Developmental differences were also found in regions in posterior parietal cortex, anterior prefrontal cortex, and insula. Overall, these results support the view that the development of episodic memory is supported by functional changes in the hippocampus as well as cortical regions.
本研究旨在考察三个年龄组在情景记忆提取中海马体和皮质对空间背景的作用的年龄相关性差异。8-9 岁和 10-11 岁的儿童以及 18-25 岁的成年人（N=48）分别在屏幕的左右两侧学习黑白线条画。当参与者试图回忆每个学习过的画最初出现在哪里时，获取功能磁共振成像（fMRI）数据。正确回忆空间来源表明成功地提取了空间背景的情景记忆。成人的海马体头和体区的活动与情景记忆的提取有关，但儿童没有。在儿童中，对识别的海马体激活的个体差异预测了正确的空间回忆率。在顶后皮质、前前额叶皮质和脑岛等区域也发现了发育差异。总的来说，这些结果支持这样一种观点，即情景记忆的发展是由海马体以及皮质区域的功能变化支持的。
