Açıkgöz Sadık Kadri, Açıkgöz Eser
Drug Metabol Drug Interact. 2013;28(3):187-9. doi: 10.1515/dmdi-2013-0021.
Artemisia absinthium, also known as wormwood, is used widely as an herbal medicine. In this report, we introduce an 82-year-old Turkish woman who was treated with warfarin for atrial fibrillation and was hospitalized for gastrointestinal bleeding as a result of extremely elevated international normalized ratio (INR) after consumption of A. absinthium. Naranjo adverse drug reaction probability scale score was 6, which indicated a probable relationship between the patient's elevated INR and her concomitant use of wormwood and warfarin. Clinicians should be vigilant about potential dangers of herbal medicines taken with conventional drugs, and patients taking drugs with a narrow therapeutic index, such as warfarin, should be educated about avoiding consumption of herbal medicines.
苦艾，也被称为艾草，被广泛用作草药。在本报告中，我们介绍了一名82岁的土耳其女性，她因心房颤动接受华法林治疗，在服用苦艾后国际标准化比值（INR）极高，导致胃肠道出血而住院。纳伦霍药物不良反应概率量表评分为6分，这表明患者INR升高与她同时使用艾草和华法林之间可能存在关联。临床医生应警惕草药与传统药物同时服用的潜在危险，对于服用治疗指数窄的药物（如华法林）的患者，应告知其避免食用草药。
