一种改进的 19 取代geldanamycin 途径作为新型 HSP90 抑制剂 - 在癌症和神经退行性疾病中的潜在治疗方法。
An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.
机构信息
School of Chemistry, University of Nottingham, University Park, Nottingham, UKNG7 2RD.
出版信息
Chem Commun (Camb). 2013 Oct 4;49(76):8441-3. doi: 10.1039/c3cc43457e.
Abstract
19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids.
摘要
19-取代格尔德霉素衍生物是高效的 HSP90 抑制剂，没有与其他苯醌安莎霉素相关的毒性，因此它们有可能作为癌症和神经退行性疾病的分子治疗药物。本文报道了一种新的合成这些重要化合物的方法，无需使用有毒金属和类金属。
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