Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, 1918 University Blvd., MCLM894, Birmingham, AL 35294-0005, USA.
Cell Immunol. 2013 Apr;282(2):71-8. doi: 10.1016/j.cellimm.2013.04.009. Epub 2013 May 3.
In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH induction after treatment with GHRH. Taken together, the data for the first time show alterations in GH synthesis and expression of the GHRH receptor on cells of the immune system that may play a role in the immune response in aging.
在本研究中，我们表明衰老动物的脾细胞中表达的淋巴细胞 GH 水平高于年轻动物。此外，与年轻动物相比，初级和次级免疫组织中的白细胞以及衰老大鼠的脾 T 细胞和 B 细胞均表达更高水平的 GHRH 受体。骨髓和脾 T 细胞在衰老动物中表达最高水平的 GHRH 受体。用 GHRH 处理后，衰老动物的脾细胞的增殖或 GH 诱导没有明显变化。总之，这些数据首次表明，免疫系统细胞中的 GH 合成和 GHRH 受体表达发生改变，这可能在衰老时的免疫反应中发挥作用。
