Vijayan V, Rachel T
Sabah Women & Children Hospital, Kota Kinabalu, Sabah, Malaysia.
Med J Malaysia. 2012 Dec;67(6):591-4.
The anticoagulation of choice for mechanical heart valves is the oral anticoagulant warfarin. Warfarin is associated with increased risk of miscarriage, intrauterine fetal deaths and warfarin embryopathy. This longitudical cross-over study of 5 women observed all 5 having livebirths of healthy infants after heparin-managed pregnancies. Their earlier 8 pregnancies had all resulted in perinatal losses or miscarriages when on regimes based on warfarin.
对于机械心脏瓣膜，首选的抗凝药物是口服抗凝剂华法林。华法林与流产、宫内胎儿死亡和华法林胚胎病风险增加有关。这项对5名女性进行的纵向交叉研究观察到，在肝素管理的孕期后，所有5名女性均顺利产下健康婴儿。她们之前的8次怀孕在使用基于华法林的方案时均导致围产期损失或流产。
