Anusha B, Philip R, Norain K, Harvinder S, Gurdeep S M
Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia.
Med J Malaysia. 2012 Dec;67(6):641-3.
Nasopharyngeal carcinoma (NPC) is rare among people of Indian ethnicity. A short retrospective case review of clinical records of Indian patients diagnosed with nasopharyngeal carcinoma in a period of 5 years was conducted. Their slides were further subjected to EBV encoded RNA (EBER) - In- situ Hybridization (ISH). The histologic subtype was nonkeratinizing carcinoma in all 4 patients. All were Epstein Barr Virus (EBV) positive. We believe that the crucial factor responsible for nasopharyngeal carcinoma is genetics; either a genetic susceptibility among high risk groups or genetic resistance/immunity in low risk groups. Further genetic studies are required to look for somatic or inherited chromosomal mutations among the various risk populations.
鼻咽癌在印度裔人群中较为罕见。对5年内确诊为鼻咽癌的印度患者的临床记录进行了简短的回顾性病例分析。他们的切片进一步进行了EB病毒编码RNA（EBER）原位杂交（ISH）检测。所有4例患者的组织学亚型均为非角化癌。所有患者的EB病毒（EBV）均呈阳性。我们认为，导致鼻咽癌的关键因素是遗传学；要么是高危人群中的遗传易感性，要么是低危人群中的遗传抗性/免疫性。需要进一步开展遗传学研究，以寻找不同风险人群中的体细胞或遗传性染色体突变。
