血清 25-羟维生素 D 与中国健康女性人群胰岛素抵抗和β细胞功能的关系。
Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.
机构信息
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
出版信息
Acta Pharmacol Sin. 2013 Aug;34(8):1070-4. doi: 10.1038/aps.2013.13. Epub 2013 Jun 17.
Abstract
AIM
To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.
METHODS
This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively.
RESULTS
Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca(2+) and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001).
CONCLUSION
Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.
摘要
目的
评估健康中国女性人群血清 25-羟维生素 D 水平与胰岛素抵抗和β细胞功能的相关性。
方法
本横断面研究纳入了 1382 名无 2 型糖尿病的女性参与者，她们均来自上海。在冬季采集血样，并测定血清 25-羟维生素 D、空腹血糖和胰岛素以及其他生化参数的水平。采用稳态模型评估胰岛素抵抗（HOMA-IR）和β细胞功能（HOMA-B）分别评估胰岛素抵抗和β细胞功能。
结果
经年龄、甲状旁腺激素、Ca(2+)和 BMI 校正的多元线性回归分析显示，血清 25-羟维生素 D 水平与 HOMA-IR（P<0.001）和 HOMA-B（P=0.001）之间存在独立的负相关关系。
结论
在健康的中国女性人群中，血清维生素 D 水平与胰岛素抵抗和β细胞功能显著且独立相关。
相似文献
1
Association of serum 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.血清 25-羟维生素 D 与中国健康女性人群胰岛素抵抗和β细胞功能的关系。
Acta Pharmacol Sin. 2013 Aug;34(8):1070-4. doi: 10.1038/aps.2013.13. Epub 2013 Jun 17.
2
Association between serum 25-hydroxyvitamin D level and insulin resistance in a rural population.农村人群血清25-羟维生素D水平与胰岛素抵抗之间的关联
Yonsei Med J. 2014 Jul;55(4):1036-41. doi: 10.3349/ymj.2014.55.4.1036.
3
Independent association of vitamin D and insulin resistance in obstructive sleep apnea.阻塞性睡眠呼吸暂停中维生素 D 与胰岛素抵抗的独立相关性。
Ann Endocrinol (Paris). 2019 Nov;80(5-6):319-323. doi: 10.1016/j.ando.2019.09.004. Epub 2019 Nov 1.
4
Serum 25-hydroxyvitamin D and markers of insulin resistance in a Japanese working population.血清 25-羟维生素 D 与日本劳动人群胰岛素抵抗标志物的关系。
Eur J Clin Nutr. 2012 Dec;66(12):1323-8. doi: 10.1038/ejcn.2012.169. Epub 2012 Oct 24.
5
Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000.基线血清25-羟基维生素D可预测未来血糖状态和胰岛素抵抗：医学研究委员会伊利前瞻性研究（1990 - 2000年）
Diabetes. 2008 Oct;57(10):2619-25. doi: 10.2337/db08-0593. Epub 2008 Jun 30.
6
Serum 25-hydroxyvitamin D is not associated with insulin resistance or beta cell function in Canadian Cree.血清 25-羟维生素 D 与加拿大克里族人群的胰岛素抵抗或β细胞功能无关。
J Nutr. 2011 Feb;141(2):290-5. doi: 10.3945/jn.110.129619. Epub 2010 Dec 22.
7
Sex-Specific Association of Serum 25-Hydroxyvitamin D with Insulin Resistance in Chinese Han Patients with Newly Diagnosed Type 2 Diabetes Mellitus.中国汉族初诊2型糖尿病患者血清25-羟基维生素D与胰岛素抵抗的性别特异性关联
J Nutr Sci Vitaminol (Tokyo). 2018;64(3):173-178. doi: 10.3177/jnsv.64.173.
8
Urban-rural differences explain the association between serum 25-hydroxyvitamin D level and insulin resistance in Korea.城乡差异解释了韩国血清25-羟维生素D水平与胰岛素抵抗之间的关联。
Nutrients. 2014 Dec 11;6(12):5806-18. doi: 10.3390/nu6125806.
9
Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents.貌似健康的青少年的血清25-羟基维生素D与胰岛素抵抗
PLoS One. 2014 Jul 29;9(7):e103108. doi: 10.1371/journal.pone.0103108. eCollection 2014.
10
Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes.维生素 D 与 2 型糖尿病高危人群的胰岛素抵抗和β细胞功能障碍的关系。
Diabetes Care. 2010 Jun;33(6):1379-81. doi: 10.2337/dc09-2321. Epub 2010 Mar 9.
引用本文的文献
1
Correlation analysis of thyroid function and vitamin D levels in patients with type 2 diabetes.2型糖尿病患者甲状腺功能与维生素D水平的相关性分析
Front Endocrinol (Lausanne). 2025 Aug 14;16:1650525. doi: 10.3389/fendo.2025.1650525. eCollection 2025.
2
The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes.血清钙和维生素 D 与 2 型糖尿病患者胰岛素抵抗和β细胞功能障碍的关系。
Arch Razi Inst. 2022 Oct 31;77(5):1593-1600. doi: 10.22092/ARI.2022.357641.2081. eCollection 2022 Oct.
3
Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index among Indian adolescents.印度青少年血清25-羟基维生素D与甘油三酯-葡萄糖指数之间的关联。
BMC Nutr. 2022 Jul 25;8(1):69. doi: 10.1186/s40795-022-00568-x.
4
Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance.维生素 D 缺乏与稳态模型评估的胰岛素抵抗呈负相关。
Nutrients. 2021 Dec 3;13(12):4358. doi: 10.3390/nu13124358.
5
Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations.胰岛素抵抗与维生素 D 状态在糖尿病和非糖尿病人群中呈负相关。
Nutrients. 2021 May 21;13(6):1742. doi: 10.3390/nu13061742.
6
VITAMIN DEFICIENCY AND INSULIN RESISTANCE IN NONDIABETIC OBESE PATIENTS.非糖尿病肥胖患者的维生素缺乏与胰岛素抵抗
Acta Endocrinol (Buchar). 2016 Jul-Sep;12(3):319-327. doi: 10.4183/aeb.2016.319.
7
Vitamin D Status of Residents in Taiyuan, China and Influencing Factors.中国太原居民的维生素 D 状况及影响因素。
Nutrients. 2017 Aug 18;9(8):898. doi: 10.3390/nu9080898.
8
Investigation of vitamin D status and its correlation with insulin resistance in a Chinese population.中国人群维生素D状况及其与胰岛素抵抗的相关性研究。
Public Health Nutr. 2017 Jun;20(9):1602-1608. doi: 10.1017/S1368980017000490. Epub 2017 Apr 5.
9
Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults.非糖尿病韩国成年人中胰岛素抵抗和β细胞功能的稳态模型评估与血清25-羟基维生素D之间的关系。
J Clin Biochem Nutr. 2016 Sep;59(2):139-144. doi: 10.3164/jcbn.15-143. Epub 2016 Jun 10.
10
Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women.在健康中国女性中，血清骨钙素水平与血糖及体重指数呈负相关。
Acta Pharmacol Sin. 2014 Dec;35(12):1521-6. doi: 10.1038/aps.2014.92. Epub 2014 Oct 20.
本文引用的文献
1
Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006.肥胖和维生素 D 不足对胰岛素抵抗和 2 型糖尿病的联合影响：来自 NHANES 2001-2006 的结果。
Diabetes Care. 2012 Oct;35(10):2048-54. doi: 10.2337/dc12-0235. Epub 2012 Jun 29.
2
The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents.肥胖儿童和青少年中维生素D缺乏与青春期及胰岛素抵抗的关系。
J Pediatr Endocrinol Metab. 2012;25(1-2):83-7. doi: 10.1515/jpem-2011-0426.
3
A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans.一项随机、安慰剂对照试验，评估维生素 D 补充剂改善超重和肥胖非裔美国人血糖的效果。
Diabetes Obes Metab. 2012 Sep;14(9):789-94. doi: 10.1111/j.1463-1326.2012.01605.x. Epub 2012 May 8.
4
Vitamin D and diabetes in Koreans: analyses based on the Fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2009.维生素 D 与韩国糖尿病：基于 2008-2009 年第四次韩国国家健康与营养调查（KNHANES）的分析。
Diabet Med. 2012 Aug;29(8):1003-10. doi: 10.1111/j.1464-5491.2012.03575.x.
5
Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics.肥胖儿童和青少年在热带地区的维生素 D 状况和葡萄糖稳态。
Int J Obes (Lond). 2012 Apr;36(4):491-5. doi: 10.1038/ijo.2011.260. Epub 2012 Jan 10.
6
Vitamin D deficiency in obese children and its relationship to glucose homeostasis.肥胖儿童的维生素 D 缺乏及其与葡萄糖稳态的关系。
J Clin Endocrinol Metab. 2012 Jan;97(1):279-85. doi: 10.1210/jc.2011-1507. Epub 2011 Nov 9.
7
Vitamin D insufficiency is associated with diabetes risk in Native American children.维生素D缺乏与美国原住民儿童患糖尿病的风险相关。
Clin Pediatr (Phila). 2012 Feb;51(2):146-53. doi: 10.1177/0009922811417290. Epub 2011 Oct 20.
8
Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents.低 25(OH)D3 水平与白种人儿童和青少年的总体肥胖、代谢综合征和高血压有关。
Eur J Endocrinol. 2011 Oct;165(4):603-11. doi: 10.1530/EJE-11-0545. Epub 2011 Jul 13.
9
Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus.血清钙与空腹血糖和胰岛素抵抗呈正相关，与甲状旁腺激素无关，在 2 型糖尿病男性患者中。
Metabolism. 2011 Sep;60(9):1334-9. doi: 10.1016/j.metabol.2011.02.003. Epub 2011 Apr 12.
10
Parathyroid hormone is a plausible mediator for the metabolic syndrome in the morbidly obese: a cross-sectional study.甲状旁腺激素可能是病态肥胖代谢综合征的中介：一项横断面研究。
Cardiovasc Diabetol. 2011 Feb 10;10:17. doi: 10.1186/1475-2840-10-17.
Zotero 插件