Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN 55455, USA.
Infection. 2013 Aug;41(4):757-9. doi: 10.1007/s15010-013-0486-z. Epub 2013 Jun 15.
While histoplasmosis has been reported from most continents, the disease is most often recognized in the midwestern United States. The recent diagnosis of adrenal hypofunction in two patients with progressive disseminated histoplasmosis (PDH) in our hospital led us to review the literature.
We reviewed PubMed using the search term "adrenal histoplasmosis" for the years 1971 to 2012.
The results included 242 patients with adrenal histoplasmosis from either case reports or case series. Most of the reported patients were from countries not previously considered to be heavily endemic for histoplasmosis. In addition, 41.3 % of patients with adrenal involvement developed adrenal hypofunction.
As modern technology elucidates more cases of adrenal histoplasmosis, the global boundaries of endemicity are being redefined.
尽管荚膜组织胞浆菌病已在各大洲均有报道，但这种疾病在美国中西部地区最为常见。最近在我院诊断出两例播散性进行性荚膜组织胞浆菌病（PDH）患者的肾上腺功能减退症，促使我们对文献进行了回顾。
我们使用术语“肾上腺荚膜组织胞浆菌病”在 PubMed 上检索了 1971 年至 2012 年的文献。
结果包括了 242 例来自病例报告或病例系列的肾上腺荚膜组织胞浆菌病患者。报告的大多数患者来自以前未被认为是荚膜组织胞浆菌病高度流行的国家。此外，41.3%的肾上腺受累患者出现了肾上腺功能减退症。
随着现代技术阐明了更多的肾上腺荚膜组织胞浆菌病病例，地方性疾病的全球边界正在重新定义。
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