Zanotti Paola, Chirico Claudia, Gulletta Maurizio, Ardighieri Laura, Casari Salvatore, Roldan Eugenia Quiros, Izzo Ilaria, Pinsi Gabriele, Lorenzin Giovanni, Facchetti Fabio, Castelli Francesco, Focà Emanuele
Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili General Hospital, Brescia, Italy.
Pathology Unit, University of Brescia and ASST Spedali Civili General Hospital, Brescia, Italy.
Mediterr J Hematol Infect Dis. 2018 Jul 1;10(1):e2018040. doi: 10.4084/MJHID.2018.040. eCollection 2018.
Progressive disseminated histoplasmosis (PDH) is an AIDS-defining illness with a high lethality rate if not promptly treated. The wide range of its possible clinical manifestations represents the main barrier to diagnosis in non-endemic countries. Here we present a case of PDH with haemophagocytic syndrome in a newly diagnosed HIV patient and a comprehensive review of disseminated histoplasmosis focused on epidemiology, clinical features, diagnostic tools and treatment options in HIV-infected patients.
播散性组织胞浆菌病（PDH）是一种艾滋病界定疾病，若不及时治疗，致死率很高。其可能的临床表现范围广泛，这是在非流行国家进行诊断的主要障碍。在此，我们报告一例新诊断的HIV患者发生的伴有噬血细胞综合征的PDH病例，并对播散性组织胞浆菌病进行全面综述，重点关注HIV感染患者的流行病学、临床特征、诊断工具和治疗选择。
