Niu Jing-Ning, Xu Guang-Qi, Lü Ren-Rong, Huo Ran
Department of Aesthetic, Plastic, and Burn Surgery, Shandong Provincial Hospital, Jinan 250021, China.
Zhonghua Zheng Xing Wai Ke Za Zhi. 2013 Mar;29(2):100-3.
To evaluate the efficacy and safety of 1% propranolol ointment in the treatment of superficial infantile hemangiomas (IHs).
A retrospective chart review was performed on 49 children (34 female and 15 male) with a median age of 4.1 months (range, 1-10 months). A total of 58 superficial IHs were treated with 1% propranolol ointment. Topical propranolol was applied three times daily for a mean duration of 21.1 weeks (range, 5-59 weeks). Changes in the size, texture, and color of the tumor were monitored and recorded at regular intervals. The treatment response was evaluated using a 3-point scale system: good, partial, and no response. Adverse effects after medication were evaluated and managed accordingly.
Of the 49 cases, 26 (53.1%) demonstrated good response, 17 (34.7%) showed a partial response, and 6 (12.2%) had no response. The total effective rate was 87.8% . No systemic complication was observed in any of the patients.
Topical therapy with 1% propranolol ointment may be a safe and effective method for the treatment of superficial IHs and can be used as an adjuvant treatment measure during the wait-and-see period.
评估1%普萘洛尔软膏治疗婴幼儿浅表性血管瘤（IHs）的疗效和安全性。
对49例儿童（34例女性，15例男性）进行回顾性病历审查，中位年龄为4.1个月（范围1 - 10个月）。共58处浅表性IHs接受了1%普萘洛尔软膏治疗。外用普萘洛尔每天涂抹3次，平均持续时间为21.1周（范围5 - 59周）。定期监测并记录肿瘤的大小、质地和颜色变化。使用3分制系统评估治疗反应：良好、部分缓解和无反应。对用药后的不良反应进行评估并相应处理。
49例中，26例（53.1%）显示良好反应，17例（34.7%）部分缓解，6例（12.2%）无反应。总有效率为87.8%。所有患者均未观察到全身并发症。
外用1%普萘洛尔软膏治疗可能是一种安全有效的治疗浅表性IHs的方法，可作为观察期的辅助治疗措施。
