局部使用普萘洛尔凝胶作为现有血管瘤治疗方法的补充。
Topical treatment with propranolol gel as a supplement to the existing treatment of hemangiomas.
机构信息
Children's Hospital Heilbronn, Heilbronn, Germany,
出版信息
World J Pediatr. 2014 Nov;10(4):313-7. doi: 10.1007/s12519-014-0509-6. Epub 2014 Dec 17.
BACKGROUND
Systemic treatment with propranolol is proven to be effective for patients with hemangiomas with less side-effect. We used a propranolol gel for topical use on hemangiomas.
METHODS
In this retrospective study, we analyzed 148 patients who had been treated topically with propranolol gel for 12 weeks. We analyzed the data of patients and clinically gave each hemangioma a "hemangioma score" to determine the treatment success.
RESULTS
In 147 of the 148 patients, strong signs of resolution under treatment included lightening, paling, and less vascularization. The hemangioma score showed a significant decrease during the treatment. Relevant serum levels of propranolol were not found. Adverse effects were rare and not related to propranolol.
CONCLUSION
Topical treatment with propranolol gel is suitable for specific hemangiomas in addition to cryotherapy and systemic treatment with propranolol.
背景
普萘洛尔的全身治疗已被证明对副作用较小的血管瘤患者有效。我们使用普萘洛尔凝胶进行血管瘤的局部治疗。
方法
在这项回顾性研究中，我们分析了 148 名接受普萘洛尔凝胶治疗 12 周的患者。我们分析了患者的数据，并对每个血管瘤进行了“血管瘤评分”，以确定治疗的成功程度。
结果
在 148 例患者中的 147 例中，治疗过程中明显出现消退迹象，包括颜色变浅、变白和血管化减少。血管瘤评分在治疗过程中显著下降。未发现相关的普萘洛尔血清水平。不良反应罕见，与普萘洛尔无关。
结论
除冷冻疗法和普萘洛尔全身治疗外，普萘洛尔凝胶局部治疗也适用于特定的血管瘤。
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