Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Innsbruck Medical University, Innsbruck, Austria.
Transpl Int. 2013 Sep;26(9):879-85. doi: 10.1111/tri.12125. Epub 2013 Jun 17.
Surgeries performed during the night are associated with higher complication rates. The aim of this study was to determine the impact of nighttime surgery on the outcome after kidney transplantation. In all, 873 deceased donor kidney transplants were retrospectively analyzed and grouped according to the time of surgery: daytime (8 AM to 8 PM, n = 610) versus nighttime (8 PM to 8 AM, n = 263). Statistical analysis compared patient/graft survival, rate of delayed graft function (DGF), acute rejection rate, and surgical complications. One and 5-year patient and graft survival did not differ between daytime and nighttime transplants. DGF occurred in 31.1% of daytime compared to 37.6% of nighttime procedures (P = 0.06). Acute allograft rejection was observed in 22.6% of daytime compared to 18.3% in nighttime graft recipients (P = 0.15). Nighttime procedures were associated with 22.4% complications compared to 22.1% in daytime procedures (P = 0.92). Most importantly, if transplantations were postponed until the next morning, cold ischemia time (CIT) would have increased from 16.6 h to 24.6 h (P < 0.0001) which would have resulted in decreased long-term survival (P < 0.02). Nighttime kidney transplants are neither associated with a higher surgical complication rate nor worse 5-year outcomes than daytime procedures, thus are justified to keep CIT short.
夜间手术与更高的并发症发生率相关。本研究旨在确定夜间手术对肾移植后结局的影响。共回顾性分析了 873 例尸肾移植患者,并根据手术时间分为白天(8:00 至 20:00,n = 610)和夜间(20:00 至 8:00,n = 263)两组。统计分析比较了患者/移植物存活率、延迟移植物功能(DGF)发生率、急性排斥反应率和手术并发症。白天和夜间移植的 1 年和 5 年患者和移植物存活率无差异。白天 DGF 发生率为 31.1%,夜间为 37.6%(P = 0.06)。白天移植的急性同种异体排斥反应发生率为 22.6%,夜间为 18.3%(P = 0.15)。夜间手术的并发症发生率为 22.4%,白天为 22.1%(P = 0.92)。最重要的是,如果将移植推迟到第二天早上,冷缺血时间(CIT)将从 16.6 小时增加到 24.6 小时(P < 0.0001),这将导致长期存活率降低(P < 0.02)。夜间肾移植与更高的手术并发症发生率或比白天手术更差的 5 年结局无关,因此有理由保持 CIT 短。