Liu Kang, Liu Xinghan, Wang Meng, Wang Xijing, Kang Huafeng, Lin Shuai, Yang Pengtao, Dai Cong, Xu Peng, Li Shanli, Dai Zhijun
Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Oncotarget. 2016 Sep 27;7(39):62954-62965. doi: 10.18632/oncotarget.10617.
Recent studies have focused on the associations of catalase polymorphisms with various types of cancer, including cervical and prostate cancers. However, the results were inconsistent. To obtain a more reliable conclusion, we evaluated the relationship between the two common catalase gene polymorphisms (rs1001179 and rs794316) and cancer risk by a meta-analysis. Our meta-analysis included 37 published studies involving 14,942 cancer patients and 43,285 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the cancer risk. The results demonstrated that the rs1001179 polymorphism was associated with an increased cancer risk in the recessive and homozygote models (TT vs. CC: OR = 1.19, P = 0.01; TT vs. CT+CC: OR = 1.19, P <0.001). Furthermore, stratified analyses revealed a significant association between the rs1001179 polymorphism and prostate cancer in all models except the homozygote comparison. An association of the rs794316 polymorphism with cancer risk was detected in two genetic models (TT vs. AA: OR = 1.34, 95% CI = 1.03-1.74, P <0.001; TT vs. AT+AA: OR = 1.39, 95% CI = 1.09-1.77, P = 0.01). Additional well-designed studies with large samples should be performed to validate our results.
近期研究聚焦于过氧化氢酶基因多态性与包括宫颈癌和前列腺癌在内的各类癌症之间的关联。然而，结果并不一致。为得出更可靠的结论，我们通过荟萃分析评估了两种常见的过氧化氢酶基因多态性（rs1001179和rs794316）与癌症风险之间的关系。我们的荟萃分析纳入了37项已发表的研究，涉及14942例癌症患者和43285例无癌对照。采用比值比（OR）和95%置信区间（CI）来评估癌症风险。结果表明，rs1001179多态性在隐性和纯合子模型中与癌症风险增加相关（TT与CC比较：OR = 1.19，P = 0.01；TT与CT + CC比较：OR = 1.19，P <0.001）。此外，分层分析显示，除纯合子比较外，rs1001179多态性在所有模型中与前列腺癌均存在显著关联。在两种遗传模型中检测到rs794316多态性与癌症风险相关（TT与AA比较：OR = 1.34，95% CI = 1.03 - 1.74，P <0.001；TT与AT + AA比较：OR = 1.39，95% CI = 1.09 - 1.77，P = 0.01）。应开展更多设计良好的大样本研究以验证我们的结果。
