TREX1 多态性与 HIV-1 感染易感性。
Polymorphisms in TREX1 and susceptibility to HIV-1 infection.
机构信息
Department of Immunology, Institute of Biologic Sciences, University of Sao Paulo, Sao Paulo, Brazil.
出版信息
Int J Immunogenet. 2013 Dec;40(6):492-4. doi: 10.1111/iji.12071. Epub 2013 Jun 15.
PMID:23773365
Abstract
TREX-1 is a restriction factor against HIV-1. The coding sequence of TREX1 gene was analysed in HIV+ subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.
摘要
TREX-1 是一种针对 HIV-1 的限制因子。对 HIV+ 受试者的 TREX1 基因编码序列进行分析，寻找可能与 HIV 感染易感性相关的遗传变异。单核苷酸多态性 rs3135945 与 HIV 感染显著相关，强调了 TREX-1 在抗 HIV 反应中的作用。
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