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531C/T 多态性与 HIV-1 感染者的免疫状态相关的自身抗体。

531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals.

机构信息

Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.

Graduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.

出版信息

Int J Mol Sci. 2023 Jun 2;24(11):9660. doi: 10.3390/ijms24119660.

DOI:10.3390/ijms24119660
PMID:37298611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10253649/
Abstract

Autoimmune diseases can develop during HIV-1 infection, mainly related to the individual's immune competence. The study investigated the association of the 531C/T polymorphism and antinuclear antibodies (ANA) in HIV-1 infection and the time of antiretroviral therapy (ART) used. Cross-sectional and longitudinal assessments were carried out in 150 individuals, divided into three groups: ART-naïve, 5 years and 10 years on ART; ART-naïve individuals were evaluated for 2 years after initiation of treatment. The individuals' blood samples were submitted to indirect immunofluorescence tests, real-time PCR and flow cytometry. The 531C/T polymorphism was associated with higher levels of TCD4 lymphocytes and IFN-α in individuals with HIV-1. Individuals on ART had a higher frequency of ANA, higher levels of T CD4 lymphocytes, a higher ratio of T CD4/CD8 lymphocytes and higher levels of IFN-α than therapy-naïve individuals ( < 0.05). The 531C/T polymorphism was associated with better maintenance of the immune status of individuals with HIV-1 and ANA with immune restoration in individuals on ART, indicating the need to identify individuals at risk of developing an autoimmune disease.

摘要

自身免疫性疾病可在 HIV-1 感染期间发生，主要与个体的免疫能力有关。本研究调查了 HIV-1 感染中 531C/T 多态性与抗核抗体（ANA）以及抗逆转录病毒治疗（ART）时间的相关性。对 150 名个体进行了横断面和纵向评估，将其分为三组：未接受 ART 治疗、接受 ART 治疗 5 年和 10 年；ART 初治个体在开始治疗后 2 年内进行评估。对个体的血液样本进行间接免疫荧光试验、实时 PCR 和流式细胞术检测。531C/T 多态性与 HIV-1 个体中更高水平的 TCD4 淋巴细胞和 IFN-α 相关。与初治个体相比，接受 ART 的个体 ANA 频率更高、T CD4 淋巴细胞水平更高、T CD4/CD8 淋巴细胞比值更高、IFN-α 水平更高（<0.05）。531C/T 多态性与 HIV-1 个体的免疫状态更好维持以及接受 ART 治疗个体的免疫恢复相关，表明需要识别发生自身免疫性疾病风险的个体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/14e8d8c10c2b/ijms-24-09660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/16098cf26913/ijms-24-09660-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/b2d5cc7852ff/ijms-24-09660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/cadfd936e479/ijms-24-09660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/14e8d8c10c2b/ijms-24-09660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/16098cf26913/ijms-24-09660-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/b2d5cc7852ff/ijms-24-09660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/cadfd936e479/ijms-24-09660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d83/10253649/14e8d8c10c2b/ijms-24-09660-g004.jpg

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