Institute of Biomedical Technologies, National Research Council, Milan, Italy.
Maturitas. 2013 Sep;76(1):57-63. doi: 10.1016/j.maturitas.2013.05.012. Epub 2013 Jun 14.
To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women.
A population-based prospective cohort study of all residents in Bambuì, south-eastern Brazil, aged 60 years or older. Repeated BP measurements were obtained in four waves from 851 women who underwent ApoE genotyping at baseline (88.3% of those enrolled), and multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, while accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. The few measurements (2.1%) made during hormone replacement therapy were excluded from the analysis.
Alcohol consumption was associated with high levels of systolic and diastolic BP in an age×genotype-dependent manner only in the non-obese women (BMI<27 kg/m(2)). Among those with the ɛ3/3 genotype, the differences in systolic and diastolic levels between drinkers and non-drinkers estimated at the age of 60 years were respectively 13.7 mmHg (p=0.022) and 10.7 mmHg (p=0.002), and disappeared in the older age groups, in which drinking was associated with systolic/diastolic hypertension if the non-obese women were ɛ4 carriers.
In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the ɛ3/3 ApoE genotype, and late in ɛ4 carriers. We hypothesize the mediation of androgen hormones and the influence of ApoE genotypes on age at natural menopause. A better understanding of these mechanisms may guide better preventive choices.
评估载脂蛋白 E 基因型、饮酒和肥胖之间的相互作用对绝经后妇女血压（BP）水平与年龄相关趋势的影响。
这是一项在巴西东南部班布伊的所有居民中进行的基于人群的前瞻性队列研究，年龄在 60 岁或以上。在基线时对 851 名接受载脂蛋白 E 基因分型的女性进行了 4 次重复 BP 测量（招募人数的 88.3%），并使用多水平随机效应模式混合模型来评估与年龄相关的 BP 轨迹，同时考虑到不可忽略的失访/死亡和处理异质性作为随机参数变化。激素替代疗法期间进行的少数测量（2.1%）被排除在分析之外。
仅在非肥胖女性（BMI<27 kg/m(2)）中，饮酒与收缩压和舒张压呈年龄×基因型依赖性的高水平相关。在 ɛ3/3 基因型的女性中，60 岁时饮酒者和非饮酒者之间收缩压和舒张压水平的差异分别为 13.7 mmHg（p=0.022）和 10.7 mmHg（p=0.002），在年龄较大的组中消失，其中如果非肥胖女性是 ɛ4 携带者，则饮酒与收缩压/舒张压高血压相关。
在非肥胖的绝经后妇女中，饮酒与 ɛ3/3 载脂蛋白 E 基因型的女性早期的收缩压和舒张压高血压以及 ɛ4 携带者的晚期收缩压和舒张压高血压相关。我们假设雄激素激素的介导和载脂蛋白 E 基因型对自然绝经年龄的影响。更好地理解这些机制可能有助于更好的预防选择。
