[与原发性心包恶性间皮瘤相关的复发性心包炎]
[Recurrent pericarditis related to primary pericardial malignant mesothelioma].
作者信息
Smets P, Guettrot-Imbert G, Hermet M, Delevaux I, Kemeny J-L, Aumaître O, André M
机构信息
Service de médecine interne, centre hospitalier universitaire Gabriel Montpied, 58, rue Montalembert, 63000 Clermont-Ferrand cedex 1, France.
出版信息
Rev Med Interne. 2013 Sep;34(9):573-6. doi: 10.1016/j.revmed.2013.04.021. Epub 2013 Jun 14.
INTRODUCTION
Most of recurrent pericarditis are idiopathic and only 15 to 20% have a specific diagnosis. Primary pericardial mesothelioma is a rare cause of recurrent pericarditis. Diagnosis can be challenging and antedates patient's death in only 10 to 20% of cases. Histology of mesothelioma and immunohistochemistry are mandatory for the diagnosis. Median of survival before using pemetrexed was about 6 months after diagnosis.
CASE REPORT
We report the history of a 64-year-old woman for which repeated biopsy for recurrent pericarditis was necessary to diagnose a primary pericardial mesothelioma. The first biopsy had only found mesothelial hyperplasia.
CONCLUSION
This case report highlights the necessity of repeat pericardial biopsy in the case of adverse outcome.
引言
大多数复发性心包炎是特发性的，只有15%至20%有明确诊断。原发性心包间皮瘤是复发性心包炎的罕见病因。诊断具有挑战性，仅10%至20%的病例在患者死亡前得以确诊。间皮瘤的组织学检查和免疫组化是诊断的必要手段。在使用培美曲塞之前，诊断后的中位生存期约为6个月。
病例报告
我们报告一名64岁女性的病例，其复发性心包炎需反复活检才能诊断为原发性心包间皮瘤。首次活检仅发现间皮细胞增生。
结论
本病例报告强调了在出现不良结果时重复心包活检的必要性。
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