Feigin R D, Anderson D C
CRC Crit Rev Clin Lab Sci. 1975 Mar;5(4):413-67. doi: 10.3109/10408367509107050.
Human leptospirosis is a subject of increasing interest. Although this disease was frequently associated with individuals whose occupation or geographic location placed them in close proximity to wild animals or farm animals, recent cases have been particularly prevalent in young children and adolescents in urban and suburban America. Many of the recent cases have been acquired from household pets, particularly from dogs or hamsters. In particular, healthy dogs who have been immunized with leptospiral organisms, thereby creating a significant risk for their owners. This article will review the pathophysiology, clincal manifestations, laboratory diagnosis, treatment, and prevention of leptospirosis in the modern era, with particular emphasis on a more complete understanding of the epidemiology of this disorder.
人类钩端螺旋体病越来越受到关注。虽然这种疾病过去常与职业或地理位置使其接近野生动物或农场动物的个体相关，但最近在美国城市和郊区的幼儿及青少年中病例尤为普遍。许多近期病例是通过家庭宠物感染的，特别是狗或仓鼠。尤其是那些已接种钩端螺旋体疫苗的健康狗，这给它们的主人带来了很大风险。本文将回顾现代钩端螺旋体病的病理生理学、临床表现、实验室诊断、治疗及预防，特别强调对这种疾病流行病学的更全面理解。
