Yang Yeonsil, Nakai Satoshi, Oda Shiori, Nishino Hiroko, Ishii Misato, Yokoyama Hiroko, Matsuki Hideaki
Graduate School of Environment and Information Sciences, Yokohama National University.
J UOEH. 2013 Jun 1;35(2):129-35. doi: 10.7888/juoeh.35.129.
In recent years, there has been increasing interest in the relevance of environmental pollution to children's health. We investigated whether the concentrations of heavy metals in meconium can be used for the assessmet of prenatal exposure in Japan. Our study subjects were newborns whose mothers were hospitalized for childbirth at Tokai University Hospital between November 2010 and March 2011. The target compounds of this study were lead (Pb), cadmium (Cd) and arsenic (As). Meconium samples collected from 102 newborns were analyzed using ICPMS. The median concentrations of Pb and As in the meconium were 0.71 ppb and 0.03 ppb, respectively. The median concentration of Cd was below the limit of quantification. These concentration values are much lower than those used in previous studies. Further study is needed to compare the concentrations of heavy metals in biological samples and to investigate the availability of meconium for the assessment of exposure to heavy metals during pregnancy.
近年来，环境污染与儿童健康的相关性受到越来越多的关注。我们调查了日本胎粪中重金属浓度是否可用于评估产前暴露情况。我们的研究对象是2010年11月至2011年3月期间在东海大学医院住院分娩的新生儿母亲所生的新生儿。本研究的目标化合物为铅（Pb）、镉（Cd）和砷（As）。使用电感耦合等离子体质谱法（ICPMS）对从102名新生儿收集的胎粪样本进行了分析。胎粪中铅和砷的中位数浓度分别为0.71 ppb和0.03 ppb。镉的中位数浓度低于定量限。这些浓度值远低于先前研究中使用的值。需要进一步研究以比较生物样本中重金属的浓度，并调查胎粪在评估孕期重金属暴露方面的可用性。
