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1
Sequence of a cDNA encoding the platelet aggregation inhibitor trigramin.编码血小板聚集抑制剂三棱晶蛋白的cDNA序列。
Nucleic Acids Res. 1990 Jul 25;18(14):4255. doi: 10.1093/nar/18.14.4255.
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A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom.一种来自竹叶青蛇毒的强效抗血小板肽，三黄素。
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Inhibition of platelet hemostatic plug formation by trigramin, a novel RGD-peptide.新型RGD肽三棱素对血小板止血栓形成的抑制作用。
Am J Physiol. 1989 Apr;256(4 Pt 2):H1038-43. doi: 10.1152/ajpheart.1989.256.4.H1038.
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A cDNA sequence encoding a neurotoxin-homolog from Bungarus multicinctus.一种编码多环扁尾海蛇神经毒素同源物的cDNA序列。
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Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA.由cDNA核苷酸序列推导的BSC-1细胞生长抑制剂（多效素）的氨基酸序列。
Proc Natl Acad Sci U S A. 1988 Jan;85(1):79-82. doi: 10.1073/pnas.85.1.79.
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Sequence analysis of a cDNA encoding a PLA2 from the sea-snake Aipysurus laevis.对编码来自光滑剑尾海蛇的一种磷脂酶A2的cDNA进行序列分析。
Nucleic Acids Res. 1988 Sep 26;16(18):9048. doi: 10.1093/nar/16.18.9048.
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Canine endothelin-2: cDNA sequence for the mature peptide.犬内皮素-2：成熟肽的cDNA序列
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Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RGD in determining the inhibitory properties of snake-venom RGD proteins.蛇毒RGD（精氨酸-甘氨酸-天冬氨酸）蛋白对整合素αIIbβ3与固定化糖蛋白配体相互作用的优先拮抗作用。支持三肽RGD侧翼氨基酸残基在决定蛇毒RGD蛋白抑制特性中起功能作用的证据。
Biochem J. 1994 Dec 15;304 ( Pt 3)(Pt 3):929-36. doi: 10.1042/bj3040929.
9
Nucleotide sequence of a rabbit genomic DNA encoding mature endothelin-3.编码成熟内皮素-3的兔基因组DNA的核苷酸序列。
Nucleic Acids Res. 1990 Jan 25;18(2):374. doi: 10.1093/nar/18.2.374.
10
Cloning and sequencing of a bovine preproendothelin cDNA.牛前内皮素cDNA的克隆与测序
Nucleic Acids Res. 1990 Jun 25;18(12):3658. doi: 10.1093/nar/18.12.3658.

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1
Snake Venom Metalloproteinases (SVMPs): A structure-function update.蛇毒金属蛋白酶（SVMPs）：结构-功能的最新进展
Toxicon X. 2020 Jul 21;7:100052. doi: 10.1016/j.toxcx.2020.100052. eCollection 2020 Sep.
2
Antitumoral activity of snake venom proteins: new trends in cancer therapy.蛇毒蛋白的抗肿瘤活性：癌症治疗的新趋势
Biomed Res Int. 2014;2014:203639. doi: 10.1155/2014/203639. Epub 2014 Feb 13.
3
Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering.蛇毒去整合素：新型二聚体去整合素及通过二硫键工程实现的结构多样化
Biochem J. 2003 Jun 15;372(Pt 3):725-34. doi: 10.1042/BJ20021739.
4
Purification, molecular cloning and mechanism of action of graminelysin I, a snake-venom-derived metalloproteinase that induces apoptosis of human endothelial cells.禾本科溶素I的纯化、分子克隆及作用机制，一种源自蛇毒的金属蛋白酶，可诱导人内皮细胞凋亡。
Biochem J. 2001 Aug 1;357(Pt 3):719-28. doi: 10.1042/0264-6021:3570719.
5
Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.类金属蛋白酶、类解整合素、富含半胱氨酸蛋白MDC2和MDC3：在大脑中高表达的新型人类细胞解整合素
Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):93-8. doi: 10.1042/bj3340093.
6
Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors.含肽类抑制剂的解整合素金属蛋白酶II的结构。对肿瘤坏死因子α转换酶抑制剂设计的启示。
Protein Sci. 1998 Feb;7(2):283-92. doi: 10.1002/pro.5560070207.
7
ADM-1, a protein with metalloprotease- and disintegrin-like domains, is expressed in syncytial organs, sperm, and sheath cells of sensory organs in Caenorhabditis elegans.ADM-1是一种具有金属蛋白酶和去整合素样结构域的蛋白质，在秀丽隐杆线虫的合胞器官、精子和感觉器官的鞘细胞中表达。
Mol Biol Cell. 1996 Dec;7(12):1877-93. doi: 10.1091/mbc.7.12.1877.
8
The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.在精卵融合中起作用的一种蛋白质的前体区域包含一个金属蛋白酶和一个解整合素结构域：结构、功能及进化意义
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10783-7. doi: 10.1073/pnas.90.22.10783.
9
First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.蛇毒金属蛋白酶的首个结构：基质金属蛋白酶/胶原酶的原型
EMBO J. 1993 Nov;12(11):4151-7. doi: 10.1002/j.1460-2075.1993.tb06099.x.
10
Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (western diamondback rattlesnake) which inhibits platelet adhesion to collagen.猫毒抑聚集素的分子克隆与表达，一种来自西部菱斑响尾蛇（Crotalus atrox）的蛇毒蛋白，可抑制血小板与胶原蛋白的黏附。
Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):411-7. doi: 10.1042/bj3070411.

本文引用的文献

1
Trigramin: primary structure and its inhibition of von Willebrand factor binding to glycoprotein IIb/IIIa complex on human platelets.
Biochemistry. 1989 Jan 24;28(2):661-6. doi: 10.1021/bi00428a037.
2
Characterization and platelet inhibitory activity of bitistatin, a potent arginine-glycine-aspartic acid-containing peptide from the venom of the viper Bitis arietans.矛头蝮蛇毒液中一种有效的含精氨酸-甘氨酸-天冬氨酸肽bitistatin的特性及血小板抑制活性
J Biol Chem. 1989 Dec 25;264(36):21550-6.

Sequence of a cDNA encoding the platelet aggregation inhibitor trigramin.

作者信息

Neeper M P, Jacobson M A

机构信息

Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486.

出版信息

Nucleic Acids Res. 1990 Jul 25;18(14):4255. doi: 10.1093/nar/18.14.4255.

DOI:10.1093/nar/18.14.4255
PMID:2377470
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC331196/
Abstract
摘要