Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2 Piso 3, C1428EHA, Buenos Aires, Argentina.
Philos Trans A Math Phys Eng Sci. 2013 Jun 17;371(1995):20120330. doi: 10.1098/rsta.2012.0330. Print 2013 Jul 28.
Octahedral Ru(II) polypyridyl complexes constitute a superb platform to devise photoactive triggers capable of delivering entire molecules in a reliable, fast, efficient and clean way. Ruthenium coordination chemistry opens the way to caging a wide range of molecules, such as amino acids, nucleotides, neurotransmitters, fluorescent probes and genetic inducers. Contrary to other phototriggers, these Ru-based caged compounds are active with visible light, and can be photolysed even at 532 nm (green), enabling the use of simple and inexpensive equipment. These compounds are also active in the two-photon regime, a property that extends their scope to systems where IR light must be used to achieve high precision and penetrability. The state of the art and the future of ruthenium polypyridyl phototriggers are discussed, and several new applications are presented.
八面体钌（II）多吡啶配合物是设计光活性引发剂的理想平台，这些引发剂能够以可靠、快速、高效和清洁的方式输送整个分子。钌配位化学为笼状捕获各种分子（如氨基酸、核苷酸、神经递质、荧光探针和遗传诱导剂）开辟了道路。与其他光引发剂不同，这些基于 Ru 的笼状化合物在可见光下具有活性，甚至可以在 532nm（绿光）下被光解，从而可以使用简单且廉价的设备。这些化合物在双光子区域也具有活性，这一特性扩展了它们的应用范围，使其能够用于需要使用红外光以实现高精度和穿透性的系统。本文讨论了钌多吡啶光引发剂的最新进展和未来发展方向，并介绍了一些新的应用。
