Department of Obstetrics and Gynecology, Dogubeyazıt State Hospital, Aǧrı ; Department of Obstetrics and Gynecology, Atatürk Training and Research Hospital, izmir.
Onco Targets Ther. 2013 Jun 7;6:621-7. doi: 10.2147/OTT.S41069. Print 2013.
The goal of this study was to investigate the between cluster of differentiation 109 (CD109) expression and tumor diameter, invasion depth, tumor grade, presence of lymph-node metastasis, and overall survival in patients with vulvar squamous cell carcinoma, which is the most common type of vulvar cancer.
Twenty-six patients who underwent an operation for vulvar cancer between 1999 and 2009 in our clinic were included in this study. Immunohistochemical staining was performed on formalin-fixed and paraffin-embedded tissue.
Tumor diameter was not found to be significantly associated with CD109 expression, intensity of cytoplasmic staining, or combined score (P = 0.325, P = 0.169, P = 0.352, respectively). Invasion depth and combined score were also not significantly correlated with CD109 expression (P = 0.324 and P = 0.174 respectively). There was a negative correlation between invasion depth and the intensity of cytoplasmic staining (P = 0.042). There was no significant correlation between tumor stage and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.574, P = 0.389, P = 0.605, respectively). A significant positive correlation was observed between tumor grade and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.003, P = 0.018, P = 0.008, respectively). No significant difference was found between the percentages of CD109 expression in patients with positive (48%) and negative (11%) lymph nodes (P = 0.058). The percentage of CD109 expression did not significantly differ in relation to overall survival (P = 0.483).
Comprehensive and more extensive studies are needed to examine the relationship between CD109 expression and vulvar malignant lesions.
本研究旨在探讨 CD109 在簇分化 109（CD109）表达与肿瘤直径、浸润深度、肿瘤分级、淋巴结转移和外阴鳞状细胞癌患者总生存之间的关系，外阴鳞状细胞癌是外阴最常见的癌症类型。
本研究纳入了 1999 年至 2009 年在我院接受外阴癌手术的 26 例患者。对福尔马林固定和石蜡包埋组织进行免疫组织化学染色。
肿瘤直径与 CD109 表达、细胞质染色强度或联合评分均无显著相关性（P=0.325、P=0.169、P=0.352）。浸润深度和联合评分也与 CD109 表达无显著相关性（P=0.324 和 P=0.174）。浸润深度与细胞质染色强度呈负相关（P=0.042）。肿瘤分期与 CD109 表达、细胞质染色强度和联合评分均无显著相关性（P=0.574、P=0.389、P=0.605）。肿瘤分级与 CD109 表达、细胞质染色强度和联合评分呈显著正相关（P=0.003、P=0.018、P=0.008）。阳性（48%）和阴性（11%）淋巴结患者的 CD109 表达率无显著差异（P=0.058）。CD109 表达率与总生存率无显著差异（P=0.483）。
需要进行更广泛的综合研究，以检验 CD109 表达与外阴恶性病变之间的关系。
