Randhawa Gurpreet Kaur, Kullar Jagdev Singh
Department of Pharmacology, Government Medical College, Amritsar, India.
Int J Appl Basic Med Res. 2011 Jan;1(1):5-10. doi: 10.4103/2229-516X.81972.
Concept of bioenhancers or biopotentiators was first time reported in 1929 by Bose. A bioenhancer is an agent capable of enhancing bioavailability and efficacy of a drug with which it is co-administered, without any pharmacological activity of its own at therapeutic dose used. Development and consequent isolation of these molecules, such as piperine and quercetin, is considered as scientific breakthrough. A fixed drug combination (Risorine) of rifampicin, isoniazid, and piperine is the result of this research. It contains almost 60% less dose of rifampicin because of its increased bioavailability and it also prevents resistance. This concept is mentioned as yogvahi in ayurveda and was used to increase the effect of medicines by increasing oral bioavailability, decreasing adverse effects and to circumvent parenteral routes of drug administration. More such useful and economically viable drug combinations can be developed by integrating knowledge of time tested ayurveda with modern methods of research. This review is an account of these bioenhancers, available from the natural resources.
生物增强剂或生物增效剂的概念最早于1929年由博斯报道。生物增强剂是一种能够提高与其共同给药的药物的生物利用度和疗效的物质，在所用治疗剂量下其自身没有任何药理活性。这些分子（如胡椒碱和槲皮素）的开发及随后的分离被认为是科学突破。利福平、异烟肼和胡椒碱的固定药物组合（力速清）就是这项研究的成果。由于其生物利用度提高，它所含的利福平剂量几乎减少了60%，而且还能预防耐药性。这一概念在阿育吠陀中被称为“瑜伽瓦希”，用于通过提高口服生物利用度、减少不良反应以及避免药物的非肠道给药途径来增强药物效果。通过将经过时间考验的阿育吠陀知识与现代研究方法相结合，可以开发出更多这样有用且经济可行的药物组合。这篇综述介绍了这些可从自然资源中获得的生物增强剂。
