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生物增强剂:从革命性概念到推向市场。

Bioenhancers: Revolutionary concept to market.

作者信息

Atal Navin, Bedi K L

机构信息

Consultant Physician, Department of Internal Medicine, Pushpanjali Medical Center, Delhi, India.

出版信息

J Ayurveda Integr Med. 2010 Apr;1(2):96-9. doi: 10.4103/0975-9476.65073.

DOI:10.4103/0975-9476.65073
PMID:21836795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3151395/
Abstract

Treatment cost is a major concern for modern medicine in developing countries like India and systematic innovative means to reduce these costs are needed. This article reviews the concept of bioenhancers to reduce treatment costs by increasing drug bioavailability. This concept, based on the Ayurvedic system of medicine, works for a wide range of ingested substances, and has been applied to modern drugs, particularly single chemicals. It offers a fine example of the benefit of integrating an ancient system with modern medicine in both theory and practice.

摘要

治疗成本是印度等发展中国家现代医学面临的一个主要问题,因此需要系统的创新方法来降低这些成本。本文回顾了生物增强剂的概念,即通过提高药物生物利用度来降低治疗成本。这一基于阿育吠陀医学体系的概念适用于多种摄入物质,并已应用于现代药物,尤其是单一化学成分的药物。它在理论和实践上都为将古老医学体系与现代医学相结合的益处提供了一个很好的范例。

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Bioenhancers: Revolutionary concept to market.生物增强剂:从革命性概念到推向市场。
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本文引用的文献

1
Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer.与作为吸收增强剂与胡椒碱一起给药的姜黄素相比,纳米颗粒包封可使姜黄素的口服生物利用度提高至少9倍。
Eur J Pharm Sci. 2009 Jun 28;37(3-4):223-30. doi: 10.1016/j.ejps.2009.02.019. Epub 2009 Mar 10.
2
Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?受传统医学启发的药物发现方法:阿育吠陀医学能指明前进的方向吗?
Drug Discov Today. 2009 Aug;14(15-16):804-11. doi: 10.1016/j.drudis.2009.05.009. Epub 2009 May 27.
3
Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors.胡椒碱类似物作为有效的金黄色葡萄球菌NorA外排泵抑制剂。
Bioorg Med Chem. 2008 Nov 15;16(22):9847-57. doi: 10.1016/j.bmc.2008.09.042. Epub 2008 Sep 19.
4
Citral derived amides as potent bacterial NorA efflux pump inhibitors.柠檬醛衍生的酰胺作为有效的细菌诺氟沙星外排泵抑制剂。
Bioorg Med Chem. 2008 Jul 1;16(13):6535-43. doi: 10.1016/j.bmc.2008.05.030. Epub 2008 May 17.
5
Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus.胡椒碱的新型结构类似物作为金黄色葡萄球菌NorA外排泵的抑制剂
J Antimicrob Chemother. 2008 Jun;61(6):1270-6. doi: 10.1093/jac/dkn088. Epub 2008 Mar 10.
6
Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.胡椒碱,一种环丙沙星抗金黄色葡萄球菌的植物化学增强剂。
Antimicrob Agents Chemother. 2006 Feb;50(2):810-2. doi: 10.1128/AAC.50.2.810-812.2006.
7
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.胡椒碱是黑胡椒的主要成分,可抑制人类P-糖蛋白和CYP3A4。
J Pharmacol Exp Ther. 2002 Aug;302(2):645-50. doi: 10.1124/jpet.102.034728.
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Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice.
Planta Med. 2001 Mar;67(2):176-9. doi: 10.1055/s-2001-11505.
9
Permeability characteristics of piperine on oral absorption--an active alkaloid from peppers and a bioavailability enhancer.胡椒碱的口服吸收渗透特性——一种来自辣椒的活性生物碱及生物利用度增强剂。
Indian J Exp Biol. 1998 Jan;36(1):46-50.
10
Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.关于阿育吠陀草药对药物生物利用度作用的科学证据。
J Ethnopharmacol. 1981 Sep;4(2):229-32. doi: 10.1016/0378-8741(81)90037-4.