Janakiraman Kunchithapatham, Manavalan Rajappan
Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India.
Afr J Tradit Complement Altern Med. 2008 Apr 10;5(3):257-62. doi: 10.4314/ajtcam.v5i3.31281.
Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.
氨苄西林和诺氟沙星用于治疗多种细菌感染。这两种药物口服生物利用度较低。胡椒碱（20毫克/千克）是胡椒中的一种生物碱，在动物模型中，它与氨苄西林和诺氟沙星共同给药可提高其口服生物利用度。这在动物模型中上述抗生素的各种药代动力学测量指标如Cmax、Tmax、AUC和t(1/2)中得到体现。
