Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin.
作者信息
Janakiraman Kunchithapatham, Manavalan Rajappan
机构信息
Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India.
出版信息
Afr J Tradit Complement Altern Med. 2008 Apr 10;5(3):257-62. doi: 10.4314/ajtcam.v5i3.31281.
Abstract
Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.
摘要
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