亚临床甲状腺功能减退症中动脉粥样硬化的非侵入性指标。
Noninvasive indicators of atherosclerosis in subclinical hypothyroidism.
作者信息
Kilic Ismail Dogu, Tanriverdi Halil, Fenkci Semin, Akin Fulya, Uslu Sukriye, Kaftan Asuman
机构信息
Department of Cardiology, Pamukkale University School of Medicine, Denizli, Turkey.
出版信息
Indian J Endocrinol Metab. 2013 Mar;17(2):271-5. doi: 10.4103/2230-8210.109708.
INTRODUCTION
Cardiovascular system is rich in thyroid hormone receptors and is one of the major sites of action for thyroid hormones. However, the effect of subclinical hypothyroidism (SCH) on atherosclerosis has not been cleared yet.
MATERIALS AND METHODS
SCH is defined as high thyroid-stimulating hormone (TSH) levels in the presence of normal serum T4 and T3 levels. A total of 32 patients with SCH and 29 controls were included in the study. Carotid intima-media thickness, flow-mediated dilatation, and aortic distensibility were compared between the groups.
RESULTS
FMD was lower in patients with SCH than in controls. GTN-induced vasodilatation was similar in the patients with SCH and controls. There was no statistically significant difference between the patients with SCH and controls with respect to CIMT and aortic distensibility.
CONCLUSION
SCH is associated with endothelial dysfunction as established by FMD. Inconsistent results of CIMT and aortic stiffness can be explained by these parameters being measures of structural changes whereas FMD is a dynamic measure that reflects the impact of both acute and chronic influences on endothelial function.
引言
心血管系统富含甲状腺激素受体，是甲状腺激素的主要作用部位之一。然而，亚临床甲状腺功能减退（SCH）对动脉粥样硬化的影响尚未明确。
材料与方法
SCH定义为血清T4和T3水平正常但甲状腺刺激激素（TSH）水平升高。本研究共纳入32例SCH患者和29例对照。比较两组之间的颈动脉内膜中层厚度、血流介导的扩张和主动脉扩张性。
结果
SCH患者的血流介导的扩张（FMD）低于对照组。SCH患者和对照组中硝酸甘油诱导的血管扩张相似。SCH患者和对照组在颈动脉内膜中层厚度（CIMT）和主动脉扩张性方面无统计学显著差异。
结论
如FMD所证实，SCH与内皮功能障碍相关。CIMT和主动脉僵硬度结果不一致可以通过这些参数是结构变化的测量指标来解释，而FMD是反映急性和慢性影响对内皮功能作用的动态测量指标。
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