Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Blood. 2013 Aug 1;122(5):641-7. doi: 10.1182/blood-2013-01-477687. Epub 2013 Jun 18.
We developed a module of the MD Anderson Symptom Inventory (MDASI) for patients with chronic myeloid leukemia (CML). To develop the MDASI-CML, we identified CML-specific symptoms from qualitative interviews with 35 patients. A list of candidate symptoms was reduced by a panel of patients, caregivers, and clinicians to the 13 core MDASI symptom items and 6 CML-specific items; these items were subsequently administered to 30 patients. Cognitive debriefing confirmed that the items were clear, relevant, and easy to use. One additional CML-specific symptom item was added, for a total of 7. The refined MDASI-CML was administered to 152 patients once every 2 weeks for 1 year. The content, concurrent, known-group, and construct validity of the MDASI-CML were evaluated. The internal consistency and test-retest reliabilities of the module were adequate. Longitudinal analysis showed relatively stable symptom severity scores over time. The most severe symptoms were fatigue, drowsiness, disturbed sleep, muscle soreness and cramping, and trouble remembering things. Approximately one-third of the patients who completed the MDASI-CML reported persistent moderate-to-severe symptoms. The MDASI-CML is a valid and reliable symptom assessment instrument that can be used in clinical studies of symptom status in patients with CML.
我们为慢性髓性白血病（CML）患者开发了 MD 安德森症状指数（MDASI）的一个模块。为了开发 MDASI-CML，我们从 35 名患者的定性访谈中确定了 CML 特异性症状。一组患者、护理人员和临床医生将候选症状列表减少到 13 项 MDASI 核心症状项目和 6 项 CML 特异性项目；随后对 30 名患者进行了这些项目的测试。认知审阅证实这些项目清晰、相关且易于使用。又添加了一个 CML 特异性症状项目，共 7 个。经过精炼的 MDASI-CML 每两周为 152 名患者进行一次，为期 1 年。评估了 MDASI-CML 的内容、同期、已知组和结构有效性。该模块的内部一致性和重测信度是足够的。纵向分析表明，随着时间的推移，症状严重程度评分相对稳定。最严重的症状是疲劳、嗜睡、睡眠障碍、肌肉酸痛和痉挛以及记忆力减退。大约三分之一完成 MDASI-CML 的患者报告持续存在中度至重度症状。MDASI-CML 是一种有效且可靠的症状评估工具，可用于 CML 患者症状状况的临床研究。
