Department of Pediatrics, University of California-San Diego, La Jolla, California, USA.
Clin Pharmacol Ther. 2013 Jul;94(1):27-9. doi: 10.1038/clpt.2013.82.
Although solute carrier (SLC) and ATP-binding cassette (ABC) transporters are critical to the absorption, distribution, and elimination of many small-molecule drugs in children, how these transporters regulate pediatric drug handling remains unclear. For proper dosing and to diminish toxicity, we need a better understanding of how organ development and functional maturation, as well as developmental changes in systemic physiology, impact transporter-mediated drug handling at pediatric developmental stages from the preterm infant through adolescence.
尽管溶质载体 (SLC) 和 ATP 结合盒 (ABC) 转运蛋白对于许多小分子药物在儿童体内的吸收、分布和消除至关重要，但这些转运蛋白如何调节儿童的药物处理仍不清楚。为了正确给药和降低毒性，我们需要更好地了解器官发育和功能成熟以及全身生理学的发育变化如何影响从早产儿到青春期的儿科发育阶段中转运蛋白介导的药物处理。
