Lacerenza Michele, Buttafava Mauro, Renna Marco, Mora Alberto Dalla, Spinelli Lorenzo, Zappa Franco, Pifferi Antonio, Torricelli Alessandro, Tosi Alberto, Contini Davide
Dipartimento di Fisica, Politecnico di Milano, 20133 Milano, Italy.
Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, 20133 Milano, Italy.
Biomed Opt Express. 2020 Sep 28;11(10):5934-5949. doi: 10.1364/BOE.403327. eCollection 2020 Oct 1.
We present a wearable time-domain near infrared spectroscopy (TD-NIRS) system (two wavelengths, one detection channel), which fits in a backpack and performs real-time hemodynamic measurements on the brain and muscle tissues of freely moving subjects. It can provide concentration values of oxygenated hemoglobin (OHb), deoxygenated hemoglobin (HHb), total hemoglobin (tHb = OHb + HHb) and tissue oxygen saturation (StO). The system is battery-operated and can be wirelessly controlled. By following established characterization protocols for performance assessment of diffuse optics instruments, we achieved results comparable with state-of-the-art research-grade TD-NIRS systems. We also performed measurements such as finger tapping (motor cortex monitoring), breath holding (prefrontal cortex monitoring and forearm muscle monitoring), and outdoor bike riding (vastus lateralis muscle monitoring), in order to test the system capabilities in evaluating both muscle and brain hemodynamics.
我们展示了一种可穿戴的时域近红外光谱（TD-NIRS）系统（两个波长，一个检测通道），它可以装在背包中，对自由活动的受试者的大脑和肌肉组织进行实时血液动力学测量。它能够提供氧合血红蛋白（OHb）、脱氧血红蛋白（HHb）、总血红蛋白（tHb = OHb + HHb）和组织氧饱和度（StO）的浓度值。该系统由电池供电，并且可以无线控制。通过遵循已建立的用于漫射光学仪器性能评估的表征协议，我们获得了与最先进的研究级TD-NIRS系统相当的结果。我们还进行了诸如手指敲击（运动皮层监测）、屏气（前额叶皮层监测和前臂肌肉监测）以及户外骑自行车（股外侧肌监测）等测量，以测试该系统在评估肌肉和大脑血液动力学方面的能力。
