卤代化合物对红细胞的损伤。

Damage to red blood cells by halocompounds.

作者信息

Hidalgo F J, Zamora R, Tappel A L

机构信息

Department of Food Science and Technology, University of California, Davis 95616.

出版信息

Toxicol Lett. 1990 Jul;52(2):191-9. doi: 10.1016/0378-4274(90)90153-d.

DOI:10.1016/0378-4274(90)90153-d

PMID:2378002

Abstract

Twenty-five halocompounds were screened as inducers of hemoglobin degradation and lipid peroxidation in rat red blood cells (RBC). RBC activated halocompounds, and oxyhemoglobin remaining depended on the halocompounds employed. Thiobarbituric-acid-reactive substances (TBARS), an index of lipid peroxidation, also depended on the halocompound. TBARS were inversely correlated and oxyhemoglobin percentage was directly correlated with the logarithm of oral LD50 of the halocompounds (r = 0.79, P less than 0.001, and r = 0.87, P less than 0.001, respectively). For 15 halocompounds, the oral LD50 calculated as log LD50 = 0.015 (% hemoglobin) -0.05 (TBARS) were correlated (r = 0.88, P less than 0.01) with the reported oral LD50.

摘要

筛选了25种卤代化合物作为大鼠红细胞（RBC）中血红蛋白降解和脂质过氧化的诱导剂。RBC激活卤代化合物，剩余的氧合血红蛋白取决于所使用的卤代化合物。脂质过氧化指标硫代巴比妥酸反应性物质（TBARS）也取决于卤代化合物。TBARS呈负相关，氧合血红蛋白百分比与卤代化合物的口服半数致死量（LD50）的对数呈正相关（r分别为0.79，P<0.001和r为0.87，P<0.001）。对于15种卤代化合物，计算得出的口服LD50（log LD50 = 0.015（血红蛋白%）-0.05（TBARS））与报道的口服LD50相关（r = 0.88，P<0.01）。