Graboyes Evan M, Allen Clint T, Chernock Rebecca D, Diaz Jason A
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, Campus Box 8115, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Ear Nose Throat J. 2013 Jun;92(6):E12. doi: 10.1177/014556131309200614.
We report the case of a 31-year-old woman with systemic lupus erythematosus who was found to have oral hairy leukoplakia (OHL). She was on immunosuppressive therapy but was human immunodeficiency virus (HIV)-negative. OHL has been previously reported in HIV-negative patients who were immunosuppressed for other reasons, such as solid organ or hematopoietic stem cell transplantation, hematologic malignancies, or systemic diseases. To the best of our knowledge, this is the first case of OHL in an HIV-negative patient reported in the otolaryngology literature. It adds to the growing list of cases of OHL in HIV-negative patients and serves as a reminder to physicians to include OHL in the differential diagnosis for oral cavity lesions in all immunosuppressed patients. The article also summarizes the current state of knowledge about the pathogenesis of OHL, its relation to the Epstein-Barr virus, and the treatment options.
我们报告了一例31岁的系统性红斑狼疮女性患者，该患者被发现患有口腔毛状白斑（OHL）。她正在接受免疫抑制治疗，但人类免疫缺陷病毒（HIV）检测为阴性。OHL此前曾在因其他原因接受免疫抑制的HIV阴性患者中报道过，如实体器官或造血干细胞移植、血液系统恶性肿瘤或全身性疾病。据我们所知，这是耳鼻喉科文献中报道的首例HIV阴性患者发生OHL的病例。它增加了HIV阴性患者中OHL病例的数量，并提醒医生在所有免疫抑制患者的口腔病变鉴别诊断中考虑OHL。本文还总结了目前关于OHL发病机制、其与爱泼斯坦-巴尔病毒的关系以及治疗选择的知识现状。
