Vivero Richard J, Dave Sandeep P, Gomez Carmen R, Weed Donald T
Department of Otolaryngology-Head and Neck Surgery, UMHC Suite 4027, 1475 Northwest 12th Ave., Miami, FL 33136, USA.
Ear Nose Throat J. 2013 Jun;92(6):E59. doi: 10.1177/014556131309200626.
We report what is to the best of our knowledge the first case of malignant transformation of a giant cell tumor of the larynx. The patient, a 34-year-old man, presented to our tertiary care university teaching hospital where he underwent hemilaryngopharyngectomy with radial forearm free flap reconstruction and 11 of 15 cycles of chemotherapy. He remained disease-free at approximately 6 years and 4 months of follow-up. The patient is decannulated and continues to have a good voice with excellent quality of life to this day. We discuss the patient's clinical course and subsequent treatment within the context of a review of the current literature regarding this disease entity. Our experience demonstrates that giant cell tumor of the larynx may present as a malignant neoplasm without adversely affecting the patient's prognosis when treated aggressively with surgical resection and adjunct chemotherapy.
据我们所知，我们报告了首例喉巨细胞瘤恶变的病例。该患者为一名34岁男性，就诊于我们的三级医疗大学教学医院，在那里他接受了半喉咽切除术并采用桡侧前臂游离皮瓣重建，以及15个周期化疗中的11个周期。在大约6年4个月的随访中，他一直无病生存。患者已拔除气管套管，至今仍保持良好嗓音，生活质量极佳。我们在回顾有关该疾病实体的当前文献的背景下讨论了患者的临床病程及后续治疗。我们的经验表明，喉巨细胞瘤可能表现为恶性肿瘤，当采用手术切除和辅助化疗积极治疗时，不会对患者的预后产生不利影响。
