Laboratory of Pharmaceutics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki-city, Kagawa 769-2193, Japan.
Anticancer Res. 2013 Jul;33(7):2807-21.
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. This discrepancy is largely attributed to its poor oral bioavailability, which may result from its poor solubility, its poor pharmacokinetic profile, or a combination of both. To circumvent these barriers, alternative drug delivery strategies and systems should be explored. In this article, after a brief review of the physicochemical properties and pharmacokinetic profiles of curcumin, recent advances in curcumin oral delivery systems are discussed.
姜黄素是一种天然多酚化合物，来源于姜黄（Curcuma longa L），已被证明是多种与炎症、增殖、生长、侵袭、药物敏感性、血管生成和癌细胞转移相关的细胞内信号通路的调节剂。尽管姜黄素在细胞培养研究中表现出显著的疗效，但在以常规口服制剂给药时，在临床研究中显示出有限的疗效。这种差异主要归因于其口服生物利用度差，这可能是由于其溶解度差、药代动力学特性差，或两者兼而有之。为了克服这些障碍，应该探索替代的药物传递策略和系统。在本文中，简要回顾了姜黄素的物理化学性质和药代动力学特征后，讨论了姜黄素口服传递系统的最新进展。
