Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Inflammopharmacology. 2023 Oct;31(5):2201-2212. doi: 10.1007/s10787-023-01265-2. Epub 2023 Jul 27.
Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including nuclear factor kappa B (NF-KB), reactive oxygen species (ROS), Wingless/Integrated (Wnt), Janus kinase-signal transducer and activator of mitogen-activated protein kinase (MAPK) and transcription (JAK/STAT). P38 belongs to the MAPKs, is known as a stress-activated MAPK and is involved in diverse biological responses. P38 is activated in various signaling cascades. P38 plays a role in inflammation, cell differentiation, proliferation, motility and survival. This cascade can serve as a therapeutic target in many disorders. Extensive evidence confirms that curcumin impacts the P38 MAPK signaling pathway, through which it exerts anti-inflammatory, neuroprotective, and apoptotic effects. Hence, curcumin can positively affect inflammatory disorders and cancers, as well as to increase glucose uptake in cells. This review discusses the pharmacological and therapeutic effects of curcumin as effected through p38 MAPK.
姜黄素（二芳基甲烷）是一种草药疗法，具有多种生物学特性，包括抗炎、抗氧化和抗癌特性。姜黄素已被证明影响多种信号通路，包括核因子 kappa B（NF-KB）、活性氧物种（ROS）、无翅/整合（Wnt）、Janus 激酶信号转导和转录激活物的丝裂原激活蛋白激酶（JAK/STAT）。p38 属于丝裂原激活蛋白激酶（MAPK），被称为应激激活的 MAPK，参与多种生物学反应。p38 在各种信号级联中被激活。p38 在炎症、细胞分化、增殖、运动和存活中发挥作用。该级联可以作为许多疾病的治疗靶点。大量证据证实，姜黄素通过 p38 MAPK 信号通路发挥作用，发挥抗炎、神经保护和凋亡作用。因此，姜黄素可以积极影响炎症性疾病和癌症，并增加细胞对葡萄糖的摄取。本文讨论了姜黄素通过 p38 MAPK 产生的药理和治疗作用。
