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[饮食疗法及补充钙剂对高血压患者磷钙稳态的影响]

[The effect of dietotherapy and supplementary calcium intake on phosphorus-calcium homeostasis in hypertensive patients].

作者信息

Gladkevich A V, Samsonov M A, Spirichev V B

出版信息

Vopr Pitan. 1990 Mar-Apr(2):23-6.

PMID:2378097
Abstract

A total of 25 patients with essential hypertension received a hyponatrium, hypocaloric antisclerotic diet providing 800 mg Ca and 1100 mg P/day, during 18-20 days. As a result of the dietotherapy, Ca concentration in the patients' blood serum rose from 9.9 +/- 0.2 to 10.4 +/- 0.1 mg/100 ml (p = 0.02), total cholesterol level was lowered from 6.58 +/- 0.43 to 5.42 +/- 0.3 mmol/l (p less than 0.05), Na+ and K+ distribution between the blood plasma and red blood cells was improved, and the arterial blood pressure was normalized in all the patients investigated. It dropped from 162 +/- 3.8/102 +/- 1.8 mm Hg before the treatment to 129 +/- 2.1/83.4 +/- 2.2 mm Hg after the treatment. Additional intake of 850 mg Ca/day, as CaCO3, decreased parathormone level in the blood serum from 0.40 +/- 0.03 to 0.23 ng/ml (p less than 0.01), intensified the hypolipidemic effect of the ration, and did not influence the degree of arterial blood pressure reduction under the action of this ration. Optimization of Ca consumption plays an important role in the combined dietotherapy of essential hypertension.

摘要

共有25例原发性高血压患者接受了低钠、低热量的抗硬化饮食,每天提供800毫克钙和1100毫克磷,持续18 - 20天。经过饮食治疗,患者血清钙浓度从9.9±0.2毫克/100毫升升至10.4±0.1毫克/100毫升(p = 0.02),总胆固醇水平从6.58±0.43毫摩尔/升降至5.42±0.3毫摩尔/升(p<0.05),血浆与红细胞之间的钠钾分布得到改善,所有接受调查的患者动脉血压均恢复正常。治疗前动脉血压为162±3.8/102±1.8毫米汞柱,治疗后降至129±2.1/83.4±2.2毫米汞柱。每天额外摄入850毫克碳酸钙形式的钙,可使血清甲状旁腺激素水平从0.40±0.03纳克/毫升降至0.23纳克/毫升(p<0.01),增强了饮食的降血脂作用,且不影响该饮食作用下动脉血压的降低程度。优化钙的摄入量在原发性高血压的联合饮食治疗中起着重要作用。

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