Nami R, Martinelli M, Zacchei F, Panza F, Pavese G, Gennari C
Minerva Cardioangiol. 1989 Mar;37(3):91-8.
Given the significance of the calcium ion in the pathogenesis of essential arterial hypertension, blood levels of total and ionised calcium, phosphorus, parathormone, blood renin activity as well as urinary calcium and phosphorus were assayed in a group of hypertensives and a comparable control group with normal blood pressure. The results showed reduced ionised calcium in the blood of the hypertensives together with hyperparathyroidism and increased calciuria. In addition, the link between parathormone and mean blood pressure levels suggests that parathormone itself play a primary role in the genesis of high blood pressure. Finally the connection between renin activity in the plasma and ionised calcium in the serum suggests that the two hormone systems are closely linked and may interact via the calcium ion.
鉴于钙离子在原发性动脉高血压发病机制中的重要性，对一组高血压患者和一组血压正常的对照人群进行了总钙、离子钙、磷、甲状旁腺激素、血肾素活性以及尿钙和尿磷的血水平检测。结果显示，高血压患者血液中的离子钙降低，同时伴有甲状旁腺功能亢进和尿钙增加。此外，甲状旁腺激素与平均血压水平之间的联系表明，甲状旁腺激素本身在高血压的发生中起主要作用。最后，血浆肾素活性与血清离子钙之间的联系表明，这两种激素系统密切相关，可能通过钙离子相互作用。
