Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Anticancer Res. 2013 Jul;33(7):2855-60.
The majority of human tumors display a high rate of glycolysis under aerobic conditions. This phenomenon was recognized approximately seven decades ago and is known as the Warburg effect. Several key enzymes required to maintain this high level of glucose metabolism are found in tumor cells. The effects of the glycolytic enzymes are known to be directly or indirectly regulated by various signaling pathways, oncogenes, suppressor genes and transcription factors. Recent molecular biology studies have shown that multiple genetic alterations are related to tumor development. Therefore, these factors may be rational targets for cancer therapy. In this short review, we describe several important molecules that affect aerobic glycolysis and discuss their possible use as therapeutic targets for cancer.
大多数人类肿瘤在有氧条件下表现出高糖酵解率。这一现象大约在七十年前被发现，被称为沃伯格效应。在肿瘤细胞中发现了几种维持这种高水平葡萄糖代谢所需的关键酶。糖酵解酶的作用被认为是直接或间接受到各种信号通路、癌基因、抑癌基因和转录因子的调节。最近的分子生物学研究表明，多种遗传改变与肿瘤的发生有关。因此，这些因素可能是癌症治疗的合理靶点。在这篇简短的综述中，我们描述了几种影响有氧糖酵解的重要分子，并讨论了它们作为癌症治疗靶点的可能用途。
