澳大利亚三匹马患马属多结节性肺纤维化。
Equine multinodular pulmonary fibrosis in three horses in Australia.
作者信息
Spelta C W, Axon J E, Begg A, Diallo I S I, Carrick J B, Russell C M, Collins N M
机构信息
Townsville Vet Clinic, 32-34 Anne St, Aitkenvale, Queensland 4814, Australia.
出版信息
Aust Vet J. 2013 Jul;91(7):274-80. doi: 10.1111/avj.12072.
BACKGROUND
Equine multinodular pulmonary fibrosis (EMPF) is a recently described form of interstitial pneumonia associated with the presence of equine herpesvirus type 5 (EHV-5). Since 2007, several case reports from America, Europe and the United Kingdom have further characterised the clinical presentation and laboratory findings of this disease.
CASE REPORTS
Three Thoroughbred broodmares were diagnosed with EMPF. Diagnosis was based on lung histopathology and positive identification of EHV-5 using PCR DNA amplification. There was multiple organ involvement in all three cases, including identification of EHV-5 in hepatic tissue in one case. Two of the three horses died. Treatment with acyclovir was unsuccessful in one horse and one horse survived without antiviral or corticosteroid treatment.
CONCLUSION
This case series is, to the authors' knowledge, the first report of EMPF in Australia and adds to the clinical description of the disease.
背景
马多结节性肺纤维化(EMPF)是一种最近被描述的间质性肺炎形式,与5型马疱疹病毒(EHV-5)的存在有关。自2007年以来,来自美国、欧洲和英国的几例病例报告进一步描述了这种疾病的临床表现和实验室检查结果。
病例报告
3匹纯种繁殖母马被诊断为EMPF。诊断基于肺组织病理学检查以及使用PCR DNA扩增技术对EHV-5的阳性鉴定。所有3例均有多个器官受累,其中1例在肝组织中鉴定出EHV-5。3匹马中有2匹死亡。1匹马使用阿昔洛韦治疗无效,1匹马未接受抗病毒或皮质类固醇治疗而存活。
结论
据作者所知,该病例系列是澳大利亚EMPF的首例报告,并补充了该疾病的临床描述。