Yeragani V K, Balon R, Pohl R, Ramesh C, Glitz D, Weinberg P, Merlos B
Adult Outpatient Department, Lafayette Clinic, Detroit, MI 48207.
Acta Psychiatr Scand. 1990 Jun;81(6):554-9. doi: 10.1111/j.1600-0447.1990.tb05498.x.
To investigate autonomic function in panic disorder patients (n = 30), we compared postural changes in heart rate and the R-R interval variance in patients and normal controls (n = 20). There was no significant difference in the immediate changes in heart rate upon standing between the groups. R-R variance was significantly decreased during resting supine condition in patients as indicated by the corrected standard deviation of the R-R intervals. The standing R-R variance was significantly lower than that of normal controls as indicated by the corrected standard deviations, the corrected mean consecutive difference and the corrected standard deviation of the mean consecutive difference of the R-R intervals, suggesting an increase in vagal withdrawal in patients, especially upon standing. If this finding is specific to panic disorder patients, it may be a useful peripheral marker for this condition.
为研究惊恐障碍患者（n = 30）的自主神经功能，我们比较了患者与正常对照者（n = 20）心率的姿势性变化及R-R间期变异性。两组之间站立时心率的即刻变化无显著差异。如通过R-R间期校正标准差所示，患者在静息仰卧位时R-R变异性显著降低。如通过R-R间期的校正标准差、校正平均连续差值及平均连续差值的校正标准差所示，站立时患者的R-R变异性显著低于正常对照者，提示患者迷走神经张力减退增加，尤其是在站立时。如果这一发现是惊恐障碍患者所特有的，那么它可能是该疾病有用的外周标志物。
