Mortimer E A, Kimura M, Cherry J D, Kuno-Sakai H, Stout M G, Dekker C L, Hayashi R, Miyamoto Y, Scott J V, Aoyama T
Department of Epidemiology, Case Western Reserve University, Cleveland, Ohio.
Am J Dis Child. 1990 Aug;144(8):899-904. doi: 10.1001/archpedi.1990.02150320063029.
The clinical efficacy of an acellular pertussis vaccine containing lymphocytosis-promoting factor, filamentous hemagglutinin, agglutinogens, and the 69-kd outer membrane protein, combined with diphtheria and tetanus toxoids and adsorbed onto an aluminum salt, was assessed in a household contact study. The occurrence of pertussis 7 to 30 days following home exposure among 62 previously vaccinated children was compared with that among 62 unvaccinated children similarly exposed. Classic whooping cough was diagnosed in 43 unimmunized children, and 1 vaccinated child experienced a 5-week illness that was probably pertussis (efficacy, 98%; 95% confidence interval, 84% to 99%). A few children in each group incurred respiratory illnesses that may have represented mild, atypical pertussis; including these as probable pertussis, vaccine efficacy was 81% (95% confidence interval, 64% to 90%). It is concluded that prior immunization with this four-component pertussis vaccine combined with diphtheria and tetanus toxoids is highly efficacious in preventing pertussis.
在一项家庭接触者研究中，评估了一种含淋巴细胞增多促进因子、丝状血凝素、凝集原和69-kd外膜蛋白的无细胞百日咳疫苗，与白喉和破伤风类毒素联合并吸附于铝盐上的临床疗效。将62名先前接种过疫苗的儿童与62名同样接触过但未接种疫苗的儿童在家庭暴露后7至30天内百日咳的发生情况进行了比较。43名未免疫儿童被诊断为典型百日咳，1名接种疫苗的儿童经历了可能是百日咳的5周病程（效力为98%；95%置信区间为84%至99%）。每组中有少数儿童患了呼吸道疾病，可能代表轻度非典型百日咳；将这些病例也算作可能的百日咳病例，疫苗效力为81%（95%置信区间为64%至90%）。结论是，先前接种这种含白喉和破伤风类毒素的四组分百日咳疫苗在预防百日咳方面非常有效。
