百日咳博德特氏菌69,000分子量外膜蛋白百日咳杆菌粘附素两种形式的生化和免疫学特性
Biochemical and immunological properties of two forms of pertactin, the 69,000-molecular-weight outer membrane protein of Bordetella pertussis.
作者信息
Gotto J W, Eckhardt T, Reilly P A, Scott J V, Cowell J L, Metcalf T N, Mountzouros K, Gibbons J J, Siegel M
机构信息
Lederle-Praxis Biologicals, American Cyanamid Company, Pearl River, New York 10965.
出版信息
Infect Immun. 1993 May;61(5):2211-5. doi: 10.1128/iai.61.5.2211-2215.1993.
Two apparent isoforms of the virulence-associated 69,000-molecular-weight protein pertactin were purified from Bordetella pertussis. Mass spectrometry showed a difference of 2,060 Da, which may result from differential C-terminal cleavage of a larger precursor. Both forms were protective in a mouse model, eliciting bactericidal antibodies and reducing respiratory tract colonization.
从百日咳博德特氏菌中纯化出了两种明显的毒力相关的69,000分子量百日咳杆菌粘附素异构体。质谱分析显示两者相差2,060道尔顿，这可能是由于较大前体的C端差异切割所致。两种形式在小鼠模型中均具有保护作用，可诱导产生杀菌抗体并减少呼吸道定植。
Zotero 插件