Rosenblum M K, Erlandson R A, Aleksic S N, Budzilovich G N
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Am J Surg Pathol. 1990 Aug;14(8):729-36. doi: 10.1097/00000478-199008000-00005.
We report two examples of melanin production by human gliomas. One was a grossly pigmented, well-differentiated ependymoma resected from the left frontoparietal region of a 13-year-old girl. The patient received radiotherapy and was free of tumor 12 years after operation. The second example was a pigmented subependymoma incidentally discovered at the autopsy of a 52-year-old man. Neoplastic cells containing an intracytoplasmic pigment satisfying histochemical criteria for melanin were present in both cases. Electron microscopic study of the melanotic ependymoma revealed electron-dense granules in the cytoplasm of cells forming rosettes. Premelanosomes were not detected. While the mechanism of melanogenesis in these cases is obscure, they support the potential of glial derivatives to produce melanin and indicate that melanogenesis in such neoplasms may have no adverse prognostic import.
我们报告了两例人类神经胶质瘤产生黑色素的病例。其中一例是从一名13岁女孩的左额顶叶区域切除的肉眼可见色素沉着、分化良好的室管膜瘤。该患者接受了放疗，术后12年无肿瘤复发。第二例是在一名52岁男性尸检时偶然发现的色素沉着室管膜下瘤。两例病例中均存在含有满足黑色素组织化学标准的胞浆内色素的肿瘤细胞。对黑色素沉着室管膜瘤的电子显微镜研究显示，形成玫瑰花结的细胞胞质中有电子致密颗粒。未检测到前黑素小体。虽然这些病例中黑色素生成的机制尚不清楚，但它们支持神经胶质衍生物产生黑色素的可能性，并表明此类肿瘤中的黑色素生成可能没有不良预后意义。
