Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China,
Arch Pharm Res. 2014 Nov;37(11):1375-9. doi: 10.1007/s12272-013-0186-3. Epub 2013 Jun 21.
Three new dibenzocyclooctadiene lignans, kadusurain A-C (1-3), together with two known compounds kadsuphilin A (4) and B (5), were isolated from an EtOAc fraction of the 80 % acetone extract of Kadsura coccinea (Lem.) A. C. Smith. Their structures were established by 1D and 2D NMR techniques, and mass spectroscopy. Anti-proliferative effect of isolated compounds was evaluated against four human tumor cell lines (A549, HCT116, HL-60, and HepG2), and it was found that compound 1 exhibited significant antiproliferative effects with IC50 values ranging from 1.05 to 12.56 μg/ml.
从八角莲（Kadsura coccinea（Lem.）A. C. Smith）80%丙酮提取物的乙酸乙酯部分中分离得到三种新的二苯并环辛二烯木脂素，卡杜沙林 A-C（1-3），以及两种已知化合物卡杜苏菲尔林 A（4）和 B（5）。通过 1D 和 2D NMR 技术以及质谱技术确定了它们的结构。对分离得到的化合物进行了对四种人肿瘤细胞系（A549、HCT116、HL-60 和 HepG2）的抗增殖活性评价，结果发现化合物 1 表现出显著的抗增殖活性，IC50 值范围为 1.05 至 12.56μg/ml。
