从垂珠五味子茎中提取的具有生物活性的二苯并环辛二烯木脂素。

Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2013 Jun 28;76(6):1052-7. doi: 10.1021/np400070x. Epub 2013 Jun 5.

DOI:10.1021/np400070x

PMID:23738539

Abstract

Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 μM, respectively.

摘要

从北五味子茎中分离得到了 7 个新的非寻常二苯并环辛二烯木脂素，即 neglignans A-G（1-7），以及 16 个已知的二苯并环辛二烯木脂素。化合物 1 和 2 是第一个在 C-4 位带有羧基的二苯并环辛二烯木脂素，化合物 3 和 4 是首次从自然界中发现的 7,8-断二苯并环辛二烯木脂素。对新化合物（1-7）和一些已知化合物进行了抗 HIV 活性和细胞毒性评价。化合物 2 和 6 表现出抗 HIV-1 活性，治疗指数值大于 50，化合物 4 对 NB4 和 SHSY5Y 癌细胞系的细胞毒性分别为 2.9 和 3.3 μM。