State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
J Nat Prod. 2013 Jun 28;76(6):1052-7. doi: 10.1021/np400070x. Epub 2013 Jun 5.
Seven new unusual dibenzocyclooctadiene lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y cancer cell lines with IC50 values of 2.9 and 3.3 μM, respectively.
从北五味子茎中分离得到了 7 个新的非寻常二苯并环辛二烯木脂素，即 neglignans A-G（1-7），以及 16 个已知的二苯并环辛二烯木脂素。化合物 1 和 2 是第一个在 C-4 位带有羧基的二苯并环辛二烯木脂素，化合物 3 和 4 是首次从自然界中发现的 7,8-断二苯并环辛二烯木脂素。对新化合物（1-7）和一些已知化合物进行了抗 HIV 活性和细胞毒性评价。化合物 2 和 6 表现出抗 HIV-1 活性，治疗指数值大于 50，化合物 4 对 NB4 和 SHSY5Y 癌细胞系的细胞毒性分别为 2.9 和 3.3 μM。
